European Respiratory Journal: 32 (4)

01 October 2008; volume 32, issue 4

Editorial

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Evaluation of guidelines for community-acquired pneumonia: a story of confounders, surprises and challenges
S. Ewig, T. Welte

European Respiratory Journal 32 (4) 823-825; DOI: 10.1183/09031936.00105008 Published 30 September 2008
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Alveolar permeability and stretch: too far, too fast
X. Trepat, R. Farré

European Respiratory Journal 32 (4) 826-828; DOI: 10.1183/09031936.00110708 Published 30 September 2008
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Lung function decline in COPD trials: bias from regression to the mean
S. Suissa

European Respiratory Journal 32 (4) 829-831; DOI: 10.1183/09031936.00103008 Published 30 September 2008

Perspective

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A dichotomy in bronchiolitis obliterans syndrome after lung transplantation revealed by azithromycin therapy
B. M. Vanaudenaerde, I. Meyts, R. Vos, N. Geudens, W. De Wever, E. K. Verbeken, D. E. Van Raemdonck, L. J. Dupont, G. M. Verleden

European Respiratory Journal 32 (4) 832-842; DOI: 10.1183/09031936.00134307 Published 30 September 2008
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COPD-related morbidity and mortality after smoking cessation: status of the evidence
N. S. Godtfredsen, T. H. Lam, T. T. Hansel, M. E. Leon, N. Gray, C. Dresler, D. M. Burns, E. Prescott, J. Vestbo

European Respiratory Journal 32 (4) 844-853; DOI: 10.1183/09031936.00160007 Published 30 September 2008

Original Articles: Cell biology of lung injury

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Frequency and peak stretch magnitude affect alveolar epithelial permeability
T. S. Cohen, K. J. Cavanaugh, S. S. Margulies

European Respiratory Journal 32 (4) 854-861; DOI: 10.1183/09031936.00141007 Published 30 September 2008
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The lectin-like domain of thrombomodulin protects against ischaemia–reperfusion lung injury
N. Geudens, M. Van de Wouwer, B. M. Vanaudenaerde, R. Vos, C. Van De Wauwer, G. M. Verleden, E. Verbeken, T. Lerut, D. E. M. Van Raemdonck, E. M. Conway

European Respiratory Journal 32 (4) 862-870; DOI: 10.1183/09031936.00157107 Published 30 September 2008

Original Articles: Cell biology of pulmonary hypertension

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Shroom expression is attenuated in pulmonary arterial hypertension
J. Sevilla-Pérez, M. Königshoff, G. Kwapiszewska, O. V. Amarie, W. Seeger, N. Weissmann, R. T. Schermuly, R. E. Morty, O. Eickelberg

European Respiratory Journal 32 (4) 871-880; DOI: 10.1183/09031936.00045507 Published 30 September 2008
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Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension
R. T. Schermuly, J-P. Stasch, S. S. Pullamsetti, R. Middendorff, D. Müller, K-D. Schlüter, A. Dingendorf, S. Hackemack, E. Kolosionek, C. Kaulen, R. Dumitrascu, N. Weissmann, J. Mittendorf, W. Klepetko, W. Seeger, H. A. Ghofrani, F. Grimminger

European Respiratory Journal 32 (4) 881-891; DOI: 10.1183/09031936.00114407 Published 30 September 2008
Supplementary materials, methods and figures

Original Articles: Community-acquired pneumonia

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Adherence to guidelines’ empirical antibiotic recommendations and community-acquired pneumonia outcome
P. G. Dambrava, A. Torres, X. Vallès, J. Mensa, M. A. Marcos, G. Peñarroja, M. Camps, R. Estruch, M. Sánchez, R. Menéndez, M. S. Niederman

European Respiratory Journal 32 (4) 892-901; DOI: 10.1183/09031936.00163407 Published 30 September 2008
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Can CAP guideline adherence improve patient outcome in internal medicine departments?
F. Blasi, I. Iori, A. Bulfoni, S. Corrao, S. Costantino, D. Legnani

European Respiratory Journal 32 (4) 902-910; DOI: 10.1183/09031936.00092607 Published 30 September 2008
Supplementary tables

Original Articles: Lung cancer

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Haem oxygenase-1 plays a central role in NNK-mediated lung carcinogenesis
M-Y. Li, J. Yip, M. K. Y. Hsin, T. S. K. Mok, Y. Wu, M. J. Underwood, G. G. Chen

European Respiratory Journal 32 (4) 911-923; DOI: 10.1183/09031936.00064508 Published 30 September 2008
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Frequent epidermal growth factor receptor gene mutations in malignant pleural effusion of lung adenocarcinoma
S-G. Wu, C-H. Gow, C-J. Yu, Y-L. Chang, C-H. Yang, Y-C. Hsu, J-Y. Shih, Y-C. Lee, P-C. Yang

European Respiratory Journal 32 (4) 924-930; DOI: 10.1183/09031936.00167407 Published 30 September 2008

Original Articles: Genetics in COPD

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Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD
S. Chappell, L. Daly, K. Morgan, T. Guetta-Baranes, J. Roca, R. Rabinovich, J. Lotya, A. B. Millar, S. C. Donnelly, V. Keatings, W. MacNee, J. Stolk, P. S. Hiemstra, M. Miniati, S. Monti, C. M. O’Connor, N. Kalsheker

European Respiratory Journal 32 (4) 931-937; DOI: 10.1183/09031936.00065308 Published 30 September 2008
Supplementary tables
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Polymorphic variation in surfactant protein B is associated with COPD exacerbations
M. G. Foreman, D. L. DeMeo, C. P. Hersh, V. J. Carey, V. S. Fan, J. J. Reilly, S. D. Shapiro, E. K. Silverman

European Respiratory Journal 32 (4) 938-944; DOI: 10.1183/09031936.00040208 Published 30 September 2008
Supplementary table

Original Articles: Clinical COPD

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Current clinical guideline definitions of airflow obstruction and COPD overdiagnosis in primary care
T. R. J. Schermer, I. J. M. Smeele, B. P. A. Thoonen, A. E. M. Lucas, J. G. Grootens, T. J. van Boxem, Y. F. Heijdra, C. van Weel

European Respiratory Journal 32 (4) 945-952; DOI: 10.1183/09031936.00170307 Published 30 September 2008
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Predictors of outcomes in COPD exacerbation cases presenting to the emergency department
N. Roche, M. Zureik, D. Soussan, F. Neukirch, D. Perrotin, the Urgence BPCO (COPD Emergency) Scientific Committee and investigators

European Respiratory Journal 32 (4) 953-961; DOI: 10.1183/09031936.00129507 Published 30 September 2008
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Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD
D. M. Mannino, D. Thorn, A. Swensen, F. Holguin

European Respiratory Journal 32 (4) 962-969; DOI: 10.1183/09031936.00012408 Published 30 September 2008

Original Articles: Asthma

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Budesonide prevents but does not reverse sustained airway hyperresponsiveness in mice
D. S. Southam, R. Ellis, J. Wattie, S. Young, M. D. Inman

European Respiratory Journal 32 (4) 970-978; DOI: 10.1183/09031936.00125307 Published 30 September 2008
Supplementary methods, results, discussion and figures
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Outdoor swimming pools and the risks of asthma and allergies during adolescence
A. Bernard, M. Nickmilder, C. Voisin

European Respiratory Journal 32 (4) 979-988; DOI: 10.1183/09031936.00114807 Published 30 September 2008
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Treatment with inhaled steroids in patients with symptoms suggestive of asthma but with normal lung function
P. Rytilä, L. Ghaly, S. Varghese, W. Chung, O. Selroos, T. Haahtela

European Respiratory Journal 32 (4) 989-996; DOI: 10.1183/09031936.00062307 Published 30 September 2008

Original Articles: Occupational exposures

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Workplace-specific challenges as a contribution to the diagnosis of occupational asthma
J-P. Rioux, J-L. Malo, J. L’Archevêque, K. Rabhi, M. Labrecque

European Respiratory Journal 32 (4) 997-1003; DOI: 10.1183/09031936.00100207 Published 30 September 2008

Original Articles: Pulmonary fibrosis

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Angiotensinogen gene G-6A polymorphism influences idiopathic pulmonary fibrosis disease progression
M. Molina-Molina, A. Xaubet, X. Li, A. Abdul-Hafez, K. Friderici, K. Jernigan, W. Fu, Q. Ding, J. Pereda, A. Serrano-Mollar, A. Casanova, E. Rodríguez-Becerra, F. Morell, J. Ancochea, C. Picado, B. D. Uhal

European Respiratory Journal 32 (4) 1004-1008; DOI: 10.1183/09031936.00015808 Published 30 September 2008

Original Articles: Sleep-disordered breathing

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CPAP decreases plasma levels of soluble tumour necrosis factor-α receptor 1 in obstructive sleep apnoea
M. A. Arias, F. García-Río, A. Alonso-Fernández, Á. Hernanz, R. Hidalgo, V. Martínez-Mateo, S. Bartolomé, L. Rodríguez-Padial

European Respiratory Journal 32 (4) 1009-1015; DOI: 10.1183/09031936.00007008 Published 30 September 2008
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Clinical and polygraphic evolution of sleep-related breathing disorders in adolescents
A. Sánchez-Armengol, A. Ruiz-García, C. Carmona-Bernal, G. Botebol-Benhamou, E. García-Díaz, J. Polo-Padillo, J. L. López-Campos, F. Capote

European Respiratory Journal 32 (4) 1016-1022; DOI: 10.1183/09031936.00133907 Published 30 September 2008

Original Articles: Tuberculosis

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Active case finding of tuberculosis in Europe: a Tuberculosis Network European Trials Group (TBNET) survey
G. H. Bothamley, L. Ditiu, G. B. Migliori, C. Lange, TBNET contributors

European Respiratory Journal 32 (4) 1023-1030; DOI: 10.1183/09031936.00011708 Published 30 September 2008
Supplementary information
CME form
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Nutritional deficit as a negative prognostic factor in patients with miliary tuberculosis
D. K. Kim, H. J. Kim, S-Y. Kwon, H-I. Yoon, C-T. Lee, Y. W. Kim, H. S. Chung, S. K. Han, Y-S. Shim, J-H. Lee

European Respiratory Journal 32 (4) 1031-1036; DOI: 10.1183/09031936.00174907 Published 30 September 2008

Original Articles: Steroids and pneumonia

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Effects of glucocorticoids in ventilated piglets with severe pneumonia
O. Sibila, C. M. Luna, C. Agustí, S. Baquero, S. Gando, J. R. Patrón, J. G. Morato, R. Absi, N. Bassi, A. Torres

European Respiratory Journal 32 (4) 1037-1046; DOI: 10.1183/09031936.00009208 Published 30 September 2008

Original Articles: Steroids and bronchiectasis

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Adrenal suppression in bronchiectasis and the impact of inhaled corticosteroids
J. Holme, J. W. Tomlinson, R. A. Stockley, P. M. Stewart, N. Barlow, A. L. Sullivan

European Respiratory Journal 32 (4) 1047-1052; DOI: 10.1183/09031936.00016908 Published 30 September 2008

Original Articles: Technological developments

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Accuracy and reliability of pulse oximetry at different arterial carbon dioxide pressure levels
X. Muñoz, F. Torres, G. Sampol, J. Rios, S. Martí, E. Escrich

European Respiratory Journal 32 (4) 1053-1059; DOI: 10.1183/09031936.00126507 Published 30 September 2008
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Validation of a single-channel airflow monitor for screening of sleep-disordered breathing
H. Nakano, T. Tanigawa, Y. Ohnishi, H. Uemori, K. Senzaki, T. Furukawa, S. Nishima

European Respiratory Journal 32 (4) 1060-1067; DOI: 10.1183/09031936.00130907 Published 30 September 2008

Review

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Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases
P-R. Burgel, J. A. Nadel

European Respiratory Journal 32 (4) 1068-1081; DOI: 10.1183/09031936.00172007 Published 30 September 2008

Series

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Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectives
P. Lévy, J-L. Pépin, C. Arnaud, R. Tamisier, J-C. Borel, M. Dematteis, D. Godin-Ribuot, C. Ribuot

European Respiratory Journal 32 (4) 1082-1095; DOI: 10.1183/09031936.00013308 Published 30 September 2008

ERS Task Force

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Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach
P. L. P. Brand, E. Baraldi, H. Bisgaard, A. L. Boner, J. A. Castro-Rodriguez, A. Custovic, J. de Blic, J. C. de Jongste, E. Eber, M. L. Everard, U. Frey, M. Gappa, L. Garcia-Marcos, J. Grigg, W. Lenney, P. Le Souëf, S. McKenzie, P. J. F. M. Merkus, F. Midulla, J. Y. Paton, G. Piacentini, P. Pohunek, G. A. Rossi, P. Seddon, M. Silverman, P. D. Sly, S. Stick, A. Valiulis, W. M. C. van Aalderen, J. H. Wildhaber, G. Wennergren, N. Wilson, Z. Zivkovic, A. Bush

European Respiratory Journal 32 (4) 1096-1110; DOI: 10.1183/09031936.00002108 Published 30 September 2008

Case Study

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Occupational asthma caused by Arabidopsis thaliana: a case of laboratory plant allergy
B. Yates, A. De Soyza, R. Harkawat, C. Stenton

European Respiratory Journal 32 (4) 1111-1112; DOI: 10.1183/09031936.00097207 Published 30 September 2008
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Lung hyperinflation: foe or friend?
M. Eichinger, S. Walterspacher, T. Scholz, K. Tetzlaff, K. Röcker, C-M. Muth, M. Puderbach, H-U. Kauczor, S. Sorichter

European Respiratory Journal 32 (4) 1113-1116; DOI: 10.1183/09031936.00118807 Published 30 September 2008
Supplementary video

Correspondence

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Passive smoking and asthma death
G. Invernizzi, R. Boffi, A. Ruprecht, A. Lazzaro, L. M. Fabbri

European Respiratory Journal 32 (4) 1117; DOI: 10.1183/09031936.00082008 Published 30 September 2008
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Exacerbations and intent-to-treat analyses in randomised trials
S. Suissa

European Respiratory Journal 32 (4) 1117-1118; DOI: 10.1183/09031936.00108308 Published 30 September 2008
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Asymptomatic airway hyperresponsiveness: what does it mean?
L-P. Boulet

European Respiratory Journal 32 (4) 1118-1119; DOI: 10.1183/09031936.00109308 Published 30 September 2008
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The effect of inhaled lidocaine–hydrofluoroalkane 134a in prednisone-dependent eosinophilic bronchitis
M. Duong, A. M. Wilson, L. Jayaram, M. Dolovich, F. Hargreave

European Respiratory Journal 32 (4) 1119-1122; DOI: 10.1183/09031936.00087108 Published 30 September 2008
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Dental units as infection sources of Pseudomonas aeruginosa
J. Barben, J. Schmid

European Respiratory Journal 32 (4) 1122-1123; DOI: 10.1183/09031936.00072808 Published 30 September 2008
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Impact of poor dental health on pneumonia
M. P. Wise, D. W. Williams, M. A. Lewis, J. G. Thomas, P. J. Frost

European Respiratory Journal 32 (4) 1123-1124; DOI: 10.1183/09031936.00096808 Published 30 September 2008
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Reproducibility of exhaled breath condensate markers
S. Chow, D. H. Yates, P. S. Thomas

European Respiratory Journal 32 (4) 1124-1126; DOI: 10.1183/09031936.00085408 Published 30 September 2008
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Exhaled breath condensate is not suitable to detect EGFR somatic mutations
A. Paradiso, S. Tommasi, R. Pinto, G. E. Carpagnano, M. P. Foschino-Barbaro

European Respiratory Journal 32 (4) 1126-1127; DOI: 10.1183/09031936.00083008 Published 30 September 2008
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The potential for patient-led COPD admission avoidance schemes
C. Iwuji, A. Rosich-Medina, N. Swaminathan, D. Baguley, C. Kirwin, K. Austin, R. J. Kurukulaaratchy

European Respiratory Journal 32 (4) 1128-1129; DOI: 10.1183/09031936.00078608 Published 30 September 2008
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Relationship between depression and exacerbations in COPD: a response
C. Laurin, K. L. Lavoie, S. L. Bacon

European Respiratory Journal 32 (4) 1129-1130; DOI: 10.1183/09031936.00079808 Published 30 September 2008
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Inhibition of the renin–angiotensin system in severe COPD
L. Mascitelli, F. Pezzetta, M. R. Goldstein

European Respiratory Journal 32 (4) 1130; DOI: 10.1183/09031936.00082308 Published 30 September 2008
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From the authors
P. M. A. Calverley, P. Albert

European Respiratory Journal 32 (4) 1131; DOI: 10.1183/09031936.00102108 Published 30 September 2008
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Massive haemoptysis: the definition should be revised
W. H. Ibrahim

European Respiratory Journal 32 (4) 1131-1132; DOI: 10.1183/09031936.00080108 Published 30 September 2008
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Mortality predictive capacity of the 6-min walk distance
G. G. Riario Sforza, C. Incorvaia

European Respiratory Journal 32 (4) 1132; DOI: 10.1183/09031936.00074408 Published 30 September 2008
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From the authors
C. G. Cote

European Respiratory Journal 32 (4) 1132-1133; DOI: 10.1183/09031936.00086008 Published 30 September 2008

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Table of Contents

Editorial

Perspective

Original Articles: Cell biology of lung injury

Original Articles: Cell biology of pulmonary hypertension

Original Articles: Community-acquired pneumonia

Original Articles: Lung cancer

Original Articles: Genetics in COPD

Original Articles: Clinical COPD

Original Articles: Asthma

Original Articles: Occupational exposures

Original Articles: Pulmonary fibrosis

Original Articles: Sleep-disordered breathing

Original Articles: Tuberculosis

Original Articles: Steroids and pneumonia

Original Articles: Steroids and bronchiectasis

Original Articles: Technological developments

Review

Series

ERS Task Force

Case Study

Correspondence

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