To the Editors:
We read with interest the article by Warth et al. 1 on mediastinal angiomyolipoma and tuberous sclerosis. Apart from mediastinal angiomyolipoma, lymphangioleiomyomatosis (LAM) can occur as part of the genetic condition tuberous sclerosis 2. Since the first report by Cornog and Eterline 3, LAM has been increasingly studied for the pathological processes involved in atypical smooth muscle LAM cell proliferation. However, it has been difficult to gain complete understanding of the natural history of LAM due to its rarity. LAM tends to progress slowly and …