Onset | Tiotropium# | Placebo¶ | Risk ratio (95% CI)tiotropium/placebo |
n | Exposure | IR | n | Exposure | IR |
Any fatal event | | | | | | | |
0–ET | 31 | 516 | 6.0 | 31 | 506 | 6.1 | 0.98 (0.60, 1.61) |
0–ED | 8 | 416 | 1.9 | 7 | 380 | 1.8 | 1.04 (0.38, 2.88) |
ED–ET | 23 | 100 | 23.0 | 24 | 126 | 19.0 | 1.21 (0.68, 2.14) |
0–ED30 | 22 | 490 | 4.5 | 19 | 454 | 4.2 | 1.07 (0.58, 1.98) |
ED30–ET | 9 | 26 | 34 | 12 | 52 | 23.1 | 1.47 (0.62, 3.49) |
Cardiac fatal event | | | | | | | |
0–ET | 6 | 523 | 1.2 | 10 | 509 | 2.0 | 0.58 (0.21, 1.61) |
0–ED | 3 | 416 | 0.7 | 2 | 380 | 0.5 | 1.37 (0.23, 8.20) |
ED–ET | 3 | 107 | 2.8 | 8 | 129 | 6.2 | 0.45 (0.12, 1.70) |
0–ED30 | 3 | 491 | 0.6 | 6 | 455 | 1.3 | 0.46 (0.12, 1.85) |
ED30–ET | 3 | 32 | 9.4 | 4 | 54 | 7.4 | 1.26 (0.28, 5.65) |
Lower respiratory fatal event | | | | | | | |
0–ET | 6 | 522 | 1.2 | 10 | 509 | 2.0 | 0.59 (0.21, 1.61) |
0–ED | 3 | 416 | 0.7 | 3 | 380 | 0.8 | 0.91 (0.18, 4.52) |
ED–ET | 3 | 106 | 2.8 | 7 | 129 | 5.4 | 0.52 (0.14, 2.02) |
0–ED30 | 3 | 491 | 0.6 | 7 | 455 | 1.5 | 0.40 (0.10, 1.54) |
ED30–ET | 3 | 31 | 9.7 | 3 | 54 | 5.5 | 1.75 (0.36, 8.71) |