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Clinical and operational value of the extensively drug-resistant tuberculosis definition

G. B. Migliori, G. Besozzi, E. Girardi, K. Kliiman, C. Lange, O. S. Toungoussova, G. Ferrara, D. M. Cirillo, A. Gori, A. Matteelli, A. Spanevello, L. R. Codecasa, M. C. Raviglione
European Respiratory Journal 2007 30: 623-626; DOI: 10.1183/09031936.00077307
G. B. Migliori
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G. Besozzi
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E. Girardi
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K. Kliiman
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C. Lange
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O. S. Toungoussova
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G. Ferrara
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D. M. Cirillo
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A. Gori
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A. Matteelli
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A. Spanevello
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L. R. Codecasa
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M. C. Raviglione
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    Fig. 1—

    A Kaplan–Meier plot showing estimated proportion of treatment success (cure plus treatment completion) according to the drug-resistance profile in Estonia, Germany, Italy and the Russian Federation. ········: other mutidrug-resistant tuberculosis (MDR-TB) cases; - - - - -: MDR-TB cases resistant to all first-line drugs; –––––: extensively drug-resistant tuberculosis cases.

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  • Table 1—

    Outcomes of extensively drug-resistant tuberculosis (XDR-TB) and multidrug-resistant tuberculosis (MDR-TB) cases in Estonia, Germany, Italy and the Russian Federation

    Treatment successDiedDefaultFailureTransferredTotal patients completing treatment
    XDR-TB#22 (39.3)14 (25.0)8 (14.3)12 (21.4)0 (0.0)56
    MDR-TB resistant to all first-line drugs¶123 (53.7)35 (15.3)39 (17.0)29 (12.7)3 (1.3)229
    Other MDR-TB+42 (66.7)8 (12.7)10 (15.9)3 (4.8)0 (0.0)63
    Total187 (53.7)57 (16.4)57 (16.4)44 (12.6)3 (0.9)348
    • Data are presented as n (%) or n. #: resistance to at least rifampin and isoniazid (definition of MDR-TB) in addition to any fluoroquinolone, and at least one of the three injectable anti-TB drugs (capreomycin, kanamycin and amikacin); ¶: cases resistant to isoniazid, rifampicin ethambutol, streptomycin and, when tested, pyrazinamide; +: cases susceptible to at least one first-line anti-TB drug. Default and transferred cases included in this table were removed from the analysis presented in the text.

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Clinical and operational value of the extensively drug-resistant tuberculosis definition
G. B. Migliori, G. Besozzi, E. Girardi, K. Kliiman, C. Lange, O. S. Toungoussova, G. Ferrara, D. M. Cirillo, A. Gori, A. Matteelli, A. Spanevello, L. R. Codecasa, M. C. Raviglione
European Respiratory Journal Oct 2007, 30 (4) 623-626; DOI: 10.1183/09031936.00077307

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Clinical and operational value of the extensively drug-resistant tuberculosis definition
G. B. Migliori, G. Besozzi, E. Girardi, K. Kliiman, C. Lange, O. S. Toungoussova, G. Ferrara, D. M. Cirillo, A. Gori, A. Matteelli, A. Spanevello, L. R. Codecasa, M. C. Raviglione
European Respiratory Journal Oct 2007, 30 (4) 623-626; DOI: 10.1183/09031936.00077307
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