Figures
- Fig. 1—
Receiver-operating characteristic curves (––––: baseline forced expiratory volume in one second (FEV1; L; area under the curve (AUC) 0.587); ------: baseline FEV1 (% pred; AUC 0.731); –– - ––: baseline carbon monoxide diffusing capacity of the lung (DL,CO; % pred; AUC 0.701); –– - - ––: baseline predicted post-operative (ppo) FEV1 (L; by ventilation/perfusion (V′/Q′) scan; AUC 0.587); -- --: baseline ppo DL,CO (% pred; by V′/Q′ scan; AUC 0.772); – – –: predicted post-operative product (PPP; AUC 0.792); –– ––: baseline ppo FEV1 (% pred; by V′/Q′ scan; AUC 0.752); ·········: reference line (AUC 0.5). Diagonal segments are produced by ties. The PPP is the product of ppo FEV1 and ppo DL,CO (both % pred).
Tables
- Table. 1—
Pulmonary function data of lung cancer surgery patients#
FEV1 L 2.0±0.7 (1.0–4.7) FEV1 % pred 79.4±20.3 (37–119) FVC L 3.3±0.9 (2–6) FVC % pred 101±17.3 (56–155) DL,CO % pred 73.6±18.0 (33–122) DL,CO/VA % pred 85.9±20.4 (37–157) TLC % pred 106.5±15.2 (66–144) ppo FEV1 L 1.4±0.5 (0.6–3.6) ppo FEV1 % pred 55.6±15.4 (22–95) ppo DL,CO % pred 51.3±14.9 (21–92) PPP 2990±1445 (560–8423) Data are presented as mean±sd (range). FEV1: forced expiratory volume in one second; % pred: percentage of the predicted value; FVC: forced vital capacity; DL,CO: carbon monoxide diffusing capacity of the lung; VA: alveolar volume; TLC: total lung capacity; ppo FEV1: predicted post-operative FEV1; ppo DL,CO: predicted post-operative DL,CO; PPP: predicted post-operative product (product of ppo FEV1 and ppo DL,CO (both % pred)). #: n = 110.
- Table. 2—
Frequency of major complications comprising complicated post-operative course and poor outcome
Complication Complicated course Poor outcome Subjects# n 28 14 Death within 30 days 4 4 Myocardial infarction 3 Cardiac failure 3 Renal failure 3 Respiratory failure 11 11 Sepsis 3 Pneumonia 21 Pulmonary embolism 2 Data are presented as n. #: some had more than one major complication.
- Table. 3—
Pulmonary function data for patients with and without a complicated post-operative course
Uncomplicated Complicated Difference (95% CI) p-value Subjects n 82 28 FEV1 L 2.0±0.6 1.9±0.8 0.1 (−0.2–0.4) 0.44 FEV1 % pred 82.9±19.5 69.6±19.4 13.4 (4.9–21.8) 0.002 FVC L 3.2±0.8 3.4±1.0 −0.2 (−0.6–0.2) 0.24 FVC % pred 102.4±17.7 96.7±15.6 5.7 (-1.8–13.2) 0.13 DL,CO % pred 76.4±17.9 65.0±15.9 11.4 (3.9–19.1) 0.004 ppo FEV1 L 1.4±0.5 1.3±0.5 0.1 (−0.1–0.3) 0.34 ppo FEV1 % pred 58.0±14.5 49.2±16.4 8.8 (3.3–15.3) 0.009 ppo DL,CO % pred 53.8±14.8 44.8±13.1 9.0 (2.5–15.4) 0.007 PPP 3228±1428 2346±1309 882 (257–1507) 0.006 Data are presented as mean±sd, unless otherwise stated. CI: confidence interval; FEV1: forced expiratory volume in one second; % pred: percentage of the predicted value; FVC: forced vital capacity; DL,CO: carbon monoxide diffusing capacity of the lung; ppo FEV1: predicted post-operative FEV1; ppo DL,CO: predicted post-operative DL,CO; PPP: predicted post-operative product (product of ppo FEV1 and ppo DL,CO (both % pred)).
- Table. 4—
Pulmonary function data for patients with and without a poor outcome
Satisfactory outcome Poor outcome Difference (95% CI) p-value Subjects n 96 14 FEV1 L 2.0±0.6 1.9±0.9 0.2 (−0.2–0.5) 0.42 FEV1 % pred 81.8±19.5 63.0±18.4 18.8 (7.8–29.8) 0.001 FVC L 3.2±0.8 3.6±1.1 −0.3 (−0.8–0.2) 0.18 FVC % pred 102.0±17.9 93.6±10.3 8.4 (-1.3–18.1) 0.01 DL,CO % pred 75.7±17.1 59.7±17.7 15.9 (6.2–25.7) 0.002 ppo FEV1 L 1.4±0.5 1.±0.5 0.2 (−0.1–0.5) 0.12 ppo FEV1 % pred 57.7±14.7 42.0±13.0 15.7 (7.5–24.0) <0.001 ppo DL,CO % pred 53.5±14.6 37.9±8.3 15.6 (7.6–23.5) <0.001 PPP 3209±1417 1644±705 1564 (796–2333) <0.001 Data are presented as mean±sd, unless otherwise stated. CI: confidence interval; FEV1: forced expiratory volume in one second; % pred: percentage of the predicted value; FVC: forced vital capacity; DL,CO: carbon monoxide diffusing capacity of the lung; ppo FEV1: predicted post-operative FEV1; ppo DL,CO: predicted post-operative DL,CO; PPP: predicted post-operative product (product of ppo FEV1 and ppo DL,CO (both % pred)).
