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Pulmonary fibrosis in an individual occupationally exposed to inhaled indium-tin oxide

S. Homma, A. Miyamoto, S. Sakamoto, K. Kishi, N. Motoi, K. Yoshimura
European Respiratory Journal 2005 25: 200-204; DOI: 10.1183/09031936.04.10012704
S. Homma
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A. Miyamoto
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S. Sakamoto
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K. Kishi
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N. Motoi
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K. Yoshimura
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  • Fig. 1—
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    Fig. 1—

    Chest computed tomography scan on admission. a) Diffusely scattered centrilobular fine nodular densities associated with emphysematous low attenuation areas in both apexes. b) Increased diffuse ground-glass opacities adjacent to peripheral air space consolidation in the right upper lung field.

  • Fig. 2—
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    Fig. 2—

    Microscopic evaluation of the video-assisted thoracic surgery biopsied lung specimen from the posterior segment of the right upper lobe. a) A proliferative peribronchial fibrosis with cholesterol clefts in the centrilobular region. b) Numerous cholesterol clefts in the interstitium and intra-alveolar spaces. c) Alveolitis associated with intra-alveolar accumulation of alveolar macrophages containing brown particles and cholesterol clefts. d) Magnified view of the intra-alveolar macrophages. Haematoxylin and eosin stain was used. Scale bars: a) 0.5 mm, b) 0.25 mm, c) 25 µm, d) 10 µm.

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    Fig. 3—

    Microanalysis of the biopsied lung specimen. a) Alveolitis with intra-alveolar accumulation of alveolar macrophages and numerous cholesterol clefts (haematoxylin and eosin stain). Scale bar = 0.5 mm. b) Electron probe X-ray microanalysis of a). The scattered small, white particles represent indium. c) Field emission-scanning electron microscopy and energy dispersive X-ray analytical spectrometer studies on the lung tissues. Three peaks of indium are indicated by arrows.

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  • Table 1—

    Results of semiquantitative analysis by electron probe X-ray

    In61.24
    Si12.12
    O8.68
    Al6.53
    Sn4.32
    Fe1.52
    P0.84
    S0.66
    Na0.45
    Cl0.23
    Mg0.20
    • Results shown as % component of particles (corresponds to fig. 3b⇑).

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Pulmonary fibrosis in an individual occupationally exposed to inhaled indium-tin oxide
S. Homma, A. Miyamoto, S. Sakamoto, K. Kishi, N. Motoi, K. Yoshimura
European Respiratory Journal Jan 2005, 25 (1) 200-204; DOI: 10.1183/09031936.04.10012704

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Pulmonary fibrosis in an individual occupationally exposed to inhaled indium-tin oxide
S. Homma, A. Miyamoto, S. Sakamoto, K. Kishi, N. Motoi, K. Yoshimura
European Respiratory Journal Jan 2005, 25 (1) 200-204; DOI: 10.1183/09031936.04.10012704
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