We welcome the interest of P. Wijkstra in our paper 1. We agree that the choice of an effective interface for noninvasive ventilation (NIV) is integral to the success of this therapy and would welcome future research in the area. We acknowledge that our study was not without methodological weaknesses, a number of which we mention in the discussion of our paper 1. Whilst we would now consider a trial in naive patients, this was not the situation …
