Figures
- Fig. 1.—
Principal component analysis. Four factors had Eigenvalues ≥1.0 (······) and explained 80.8% of the variance.
Tables
- Table 1—
Varimax rotated factor pattern (placebo baseline data from all three studies)
Factor 1 2 3 4 AQLQ activities 89# 11 −12 −17 AQLQ environment 83# 7 −3 −7 AQLQ symptoms 74# 6 −40 −30 AQLQ emotions 74# 5 −21 −24 FEV1 0 92# −8 −4 PEF pm 23 84# −3 18 PEF am 15 83# 0 −11 FVC 15 80# −2 8 FEF −19 69# −12 −16 Night-time waking −24 −6 84# 15 Night-time rescue β2‐agonist −10 −6 75# 18 Night-time symptoms −25 −4 51# 44# Nights without β2‐agonist % 13 6 −77# −8 Nights without waking % 22 3 −84# −7 Short of breath daytime −42 −7 5 59# Activity limitation −48 −2 14 56# ΔPEF pm–am 17 5 −5 59# Chest tightness daytime −41 0 0 51# Wheeze daytime −23 6 16 50# Rescue β2‐agonist daytime −4 −10 18 46# Days without β2‐agonist % 4 0 −11 −44# -
For clarity of reading, all values have been multiplied by 100
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AQLQ: Asthma Quality of Life Questionnaire
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FEV1: forced expiratory volume in one second
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PEF: peak expiratory flow; FVC: forced vital capacity
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FEF: forced expiratory flow
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#: statistically significant loading on factor
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- Table 2—
Factor loading across studies and time (varimax rotation) for placebo patients only
Study number (baseline) Week (all studies) 1 2 3 0 4 8 12 AQLQ activities 1 1 1 1 1 1 1 AQLQ environment 1 1 1 1 1 1 1 AQLQ symptoms 1,3 1 1 1 1 1 1 AQLQ emotions 1 1 1 1 1 1 1 FEV1 % pred 2 2 2 2 2 2 2 PEF pm 2 2 2 2 2 2 2 PEF am 2 2 2 2 2 2 2 FVC 2 2 2 2 2 2 2 FEF 2 2 2 2 2 2 2 Night-time waking 3 3 3 3 3 3 3 Night-time β2‐agonist use 3 3 3 3 3 3 3 Night-time symptoms 3,4 3 3 3,4 3,4 4,3 4,3 Nights without β2‐agonist % 3 3 3 3 3 3 3 Nights without waking % 3 3 3 3 3 3 3 Short of breath daytime 4 4 4 4 4,1 4 4 Activity limitation 4 4,1 4,1 4 4,1 4 4 ΔPEF am–pm 1,4 4 4 4 4 4 4 Chest tightness daytime 4 4 4 4 4 4 4 Wheeze daytime 4 None None 4 4 4 4 β2‐agonist use daytime 4 4 4 4 4 4 4 Days without β2‐agonist % 4 None None 4 4 4 4 -
Factors (1, 2, 3 or 4) onto which each of the 21 items loaded with statistical significance
-
If an item loaded on two factors, the one onto which it loaded most strongly is shown first
-
AQLQ: Asthma Quality of Life Questionnaire
-
FEV1: forced expiratory volume in one second
-
PEF: peak expiratory flow
-
FVC: forced vital capacity
-
FEF: forced expiratory flow
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- Table 3—
Factor loading for salmeterol patients only
Week 0 4 8 12 AQLQ activities 1 1 1 1 AQLQ environment 1 1 1 1 AQLQ symptoms 1 1 1 1 AQLQ emotions 1 1 1 1 FEV1 % pred 2 2 2 2 PEF pm 2 2 2 2 PEF am 2 2 2 2 FVC 2 2 2 2 FEF 2 2 2 2 Night-time waking 3 3 3 3 Night-time β2‐agonist use 3 3 3 3 Night-time symptoms 3,4 3,4 4,3 4,3 Nights without β2‐agonist % 3 3 3 3 Nights without waking % 3 3 3 3 Short of breath daytime 4 4 4 4 Activity limitation 4 4 4 4 ΔPEF am–pm 4 None None None Chest tightness daytime 4 4 4 4 Wheeze daytime 4 4 4 4 β2‐agonist use daytime 4 4 4 4 Days without β2‐agonist % None 4 4 4 -
Factors (1, 2, 3 or 4) onto which each of the 21 items loaded with statistical significance
-
If an item loaded on two factors, the one onto which it loaded most strongly is shown first
-
AQLQ: Asthma Quality of Life Questionnaire
-
FEV1: forced expiratory volume in one second
-
PEF: peak expiratory flow
-
FVC: forced vital capacity
-
FEF: forced expiratory flow
-
