Fig. 2.—
a–d) Expression and function of CX3CR1 by T‐lymphocytes from pulmonary arterial hypertension (PAH) patients. Expression of CX3CR1 was analysed by flow cytometry in memory (CD45RO+) (a and c) and naive (CD45RO-) (b and d) CD4+ and CD8+ T‐lymphocytes. Results are expressed as the proportion of labelled cells for each healthy control (n=7, ▵) and PAH patient (n=7, •). *: p<0.05; # : p<0.005. e–h) In the same individuals the function of CX3CR1 was tested by monitoring actin polymerisation (•: PAH patients, n=7; ▵: healthy controls, n=7). Results show the kinetics of actin polymerisation following fractalkine addition, with time. Baseline level, before fractalkine addition, are represented as 100%. *: p<0.05. Error bars show sem. Horizontal lines show median values. Figure modified from 17.