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From the Authors

L. Wood, P.G. Gibson, M. Garg
European Respiratory Journal 2003 22: 188; DOI: 10.1183/09031936.03.00025503
L. Wood
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P.G. Gibson
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M. Garg
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From the authors:

We thank I. Horváth for his kind comments on our review “Biomarkers of lipid peroxidation, airway inflammation and asthma” 1, and agree that we have been imprecise with the use of the term “breath condensate”. The paper would be improved by replacing this term with “exhaled breath” in relation to ethane, pentane and nitric oxide measurements.

While there is an intuitive explanation for the presence of volatile substances in exhaled breath, the mechanisms by which nonvolatile substances enter expired breath are poorly understood and need to be further investigated. 8-iso-prostaglandin F2α and malondialdehyde have been measured in breath condensate as markers of lipid peroxidation 2; however, it is, as yet, unknown whether this medium can be used for reliable measurement of antioxidant defences. Analysis of total and oxidised glutathione concentrations in induced sputum indicates that sputum supernatant is suitable for this purpose 3. Hence, we stand by our conclusions in this area.

At the moment both sputum induction and breath condensate collection are promising techniques. The most useful sampling technique remains to be determined and this is an important area of future research. Comparison of both sampling methods in a head-to-head study is needed to resolve this issue.

    • © ERS Journals Ltd

    References

    1. ↵
      Wood LG, Gibson PG, Garg ML. Biomarkers of lipid peroxidation, airway inflammation and asthma. Eur Respir J 2003;21:177–186.
    2. ↵
      Paredi P, Kharitonov SA, Barnes PJ. Analysis of expired air for oxidation products. Am J Respir Crit Care Med 2002;166:S31–S37.
    3. ↵
      Dauletbaev N, Rickmann J, Viel K, Buhl R, Wagner TO, Bargon J. Glutathione in induced sputum of healthy individuals and patients with asthma. Thorax 2001;56:13–18.
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    European Respiratory Journal Jul 2003, 22 (1) 188; DOI: 10.1183/09031936.03.00025503

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    L. Wood, P.G. Gibson, M. Garg
    European Respiratory Journal Jul 2003, 22 (1) 188; DOI: 10.1183/09031936.03.00025503
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