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Sex differences in lung vulnerability to tobacco smoking

A. Langhammer, R. Johnsen, A. Gulsvik, T.L. Holmen, L. Bjermer
European Respiratory Journal 2003 21: 1017-1023; DOI: 10.1183/09031936.03.00053202
A. Langhammer
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R. Johnsen
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A. Gulsvik
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T.L. Holmen
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L. Bjermer
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  • Fig. 1.—
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    Fig. 1.—

    Participants and responders of questionnaires in the Nord-Trøndelag Health Study (HUNT) and the Bronchial Obstruction in the Nord Trøndelag (BONT) study 1995–1997. #: 5% random sample of the total population; ¶: subjects reporting ever having had asthma or asthma-related symptoms during the last 12 months, or long-standing cough; +: subjects reporting ever having had asthma or asthma-related symptoms during the last 12 months.

  • Fig. 2.—
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    Fig. 2.—

    Forced expiratory volume in one second (FEV1) in % predicted by age, among never-smokers exposed (▴) and not exposed (□) to passive smoke, and among ever-smokers (•) in a) males and b) females.

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    Fig. 3.—

    Age-adjusted forced expiratory volume in one second (FEV1) (□), forced vital capacity (FVC) (•) as % predicted and FEV1/FVC (♦) by pack-yrs in males (–) and females (═) in the total Bronchial Obstruction in the Nord Trøndelag study group (random sample 2,791 subjects and symptom group 8,150 subjects).

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    Fig. 4.—

    Proportion of subjects in the Bronchial Obstruction in the Nord Trøndelag study sample reporting respiratory symptoms by forced expiratory volume in one second (FEV1) % predicted in males (–) and females (═), adjusted by age and pack-yrs. □: wheeze or breathlessness; •: daily cough in periods; ♦: chronic bronchitis.

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    Fig. 5.—

    Forced expiratory volume in one second (FEV1) % predicted in males (–) and females (═), reporting no respiratory symptoms and respiratory symptoms with and without diagnosis of respiratory disease, by age. □: no respiratory symptoms; •: respiratory symptoms; ♦: respiratory symptoms and doctor diagnosed asthma or chronic bronchitis/emphysema.

  • Fig. 6.—
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    Fig. 6.—

    Age and pack-yrs adjusted proportions (%) reporting “very well” or “well” to questioning on self-rated global health by forced expiratory volume in one second (FEV1) and sex, with 95% confidence intervals in the total Bronchial Obstruction in the Nord Trøndelag study sample. ▴: males; ♦: females.

Tables

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  • Table 1

    Demographical data, lung function, smoke history, reported respiratory symptoms and global self-rated health (SRH), among participants in the Bronchial Obstruction in Nord-Trøndelag (BONT) study phase I random sample (5% random sample of the total population) and symptom group (those reporting ever having had asthma, ever use of asthma medications or attacks of wheezing or breathlessness during the last 12 months)

    Characteristics5% Random sampleSymptom group#
    FemalesMalesFemalesMales
    Number¶1510 (85.5)1281 (83.7)4254 (82.2)3896 (79.4)
    Age yrs49.6±16.550.1±16.150.1±17.151.5±17.0
    Weight kg70.8±12.583.7±12.472.7±14.284.4±13.7
    Height cm163.9±6.4177.4±7.1163.7±6.4176.6±6.7
    Body mass index kg·m−226.3±4.426.5±3.427.2±5.227.0±3.9
    Lung function
     FEV1 L+2.80 (96.4)3.82 (94.3)2.56 (88.6)3.40 (84.8)
     FVC L+3.44 (97.5)4.85 (97.3)3.25 (92.6)4.52 (92.2)
    Smoking habit
     Never-smoker50.741.1**43.129.7**
     Exsmoker18.929.3**19.533.9**
     Current smoker30.029.637.336.2
     Pack-yrs in ever smokers§11.5±8.815.5±14.8**12.9±9.917.9±15.6**
    Respiratory symptoms/diseases
     Attacks of wheezing or breathlessness during the last 12 months13.713.973.073.3
     Ever having had asthma8.68.454.553.4
     Ever having used asthma medication8.17.953.346.6**
     Current asthma5.64.633.830.9**
     Daily coughing in periods15.317.6**47.844.4**
     Cough with phlegm8.410.227.928.7
     Chronic bronchitis3.25.1*12.614.4*
    Global SRH
     Poor1.51.63.34.2*
     Not so good27.423.1*44.839.9**
     Good56.459.144.849.1**
     Very good14.716.17.16.8
    • Data are presented as mean±sd or mean (%) unless otherwise stated

    • #: excluded those who reported symptoms in the 5% random sample

    • ¶: (per cent of those invited to BONT phase I among participants at the main screening)

    • +: % predicted

    • §: adjusted by age. In each sample the difference by sex was tested by the Chi-squared test for proportions and variance analyses for mean number of pack-yrs

    • FEV1: forced expiratory flow in one second

    • FVC: forced vital capacity

    • SRH: self related health

    • *: p<0.05

    • **: p<0.01

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Sex differences in lung vulnerability to tobacco smoking
A. Langhammer, R. Johnsen, A. Gulsvik, T.L. Holmen, L. Bjermer
European Respiratory Journal Jun 2003, 21 (6) 1017-1023; DOI: 10.1183/09031936.03.00053202

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Sex differences in lung vulnerability to tobacco smoking
A. Langhammer, R. Johnsen, A. Gulsvik, T.L. Holmen, L. Bjermer
European Respiratory Journal Jun 2003, 21 (6) 1017-1023; DOI: 10.1183/09031936.03.00053202
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