Tables
- Table 1—
Characteristics of 87 subjects with toluene diisocyanate (TDI) asthma at the time of diagnosis and the follow-up visit
Diagnosis Follow-up Age yrs 38.0±1.2 48.7±1.2# Sex Male 63 Female 24 Smoking habits Nonsmoker 63.2% 63.2% Exsmoker 28.7% 29.9% Current smoker 8.0% 6.9% Atopic status 23.0% 28.7% Duration of exposure yrs 12.0±0.9 Duration of symptoms yrs 3.8±0.5 Current exposure Yes 15.0% No 85.0% Symptoms of asthma 100% 71.0%¶ Type of asthmatic reaction Immediate 20.7% Late alone 54.0% Dual 25.3% -
Data are presented as mean±sem unless otherwise stated
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#: significantly different from age of diagnosis by use of Mann-Whitney test
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p<0.001
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¶: significantly different from symptoms at diagnosis by use of the Chi-squared test
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p<0.001
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- Table 2—
Respiratory parameters measured at diagnosis and the follow-up visit
Diagnosis Follow-up FVC % pred 98.1±1.2¶ 94.4±1.4§ FEV1 % pred 98.8±1.6 98.1±1.7 FEV1/FVC ratio 77.4±0.8 77.1±0.7 Airway obstruction# 33.3% 37.9% FEV1/FVC <75% PD20 mg 0.466 (1.12)+ 1.042 (1.11)ƒ -
FVC: forced vital capacity
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FEV1: forced expiratory volume in one second
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PD20: provocative dose of methacholine causing a 20% fall in FEV1
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#: criteria from the American Thoracic Society
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1986 15; ¶: predicted values from Commissions des Communautes Europeennes 16
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+: geometric (G) mean and Gsem
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§: significantly different from FVC (% pred) at diagnosis
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by use of Mann-Whitney test
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p<0.05
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ƒ: significantly different from PD20 at diagnosis by use of Mann-Whitney test
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p<0.001
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- Table 3—
Summary of the stepwise logistic regression analysis for the effects of initial provocative dose causing a 20% fall in the forced expiratory volume in one second (PD20), duration of exposure, duration of follow-up and treatment with inhaled steroids among subjects with PD20 ≤1 mg and >1 mg at follow-up#
Variable Model 0 Model 1 Model 2 Model 3 Initial PD20, log dose B −2.422 −2.313 −3.42 −2.14 se 1.039 1.049 1.384 1.070 OR 0.08 0.09 0.03 0.11 CI 0.01–0.68 0.01–0.77 0.002–0.49 0.01–0.95 p-value 0.02 0.02 0.01 0.04 Duration of exposure, yrs B −0.08 −0.08 −0.13 −0.10 se 0.060 0.061 0.071 0.074 OR 0.91 0.92 0.87 0.90 CI 0.81–1.03 0.81–1.04 0.76–1.01 0.78–1.04 p-value 0.16 0.19 0.06 0.16 Last exposure to TDI yrs NI NI B 0.04 0.03 se 0.089 0.102 OR 1.04 1.03 CI 0.87–1.24 0.84–1.26 p-value 0.11 0.72 Interval since removal from exposure yrs (≥10 <10) NI B 2.02 se 1.172 OR 7.59 CI 0.76–75.6 p-value 0.08 Current inhaled steroids, yes versus no B 2.22 se 1.211 OR 9.22 CI 0.85–99.08 p-value 0.06 Prediction 82.9 82.9 87.2 82.9 -
#: dependent variable
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PD20 ≤1 mg
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Model: NI: variable not included in the model
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0: normal airway responsiveness (PD20 >1 mg)
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1: airway hyperresponsiveness (PD20 ≤1 mg)
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0: interval since removal from exposure ≥10 yrs
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1: interval since removal from exposure <10 yr
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0: no current inhaled steroids
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1: yes current inhaled steroids
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B: regression coefficient
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OR: odds ratio
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CI: 95% confidence interval
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