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Lung function in allogeneic bone marrow transplantation recipients

R Rodriguez-Roisin, J Roca, A Granena, AG Agusti, P Marin, C Rozman
European Respiratory Journal 1989 2: 359-365; DOI: 10.1183/09031936.93.02040359
R Rodriguez-Roisin
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J Roca
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A Granena
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AG Agusti
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P Marin
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C Rozman
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Abstract

In order to investigate the incidence of pulmonary function complications following bone marrow transplantation (BMT), 17 patients with leukaemia and 8 with aplastic anaemia were sequentially assessed over a one year period. Before BMT, all the patients were free of respiratory symptoms and had both normal chest X-ray and routine lung function tests. However, 5 patients disclosed airway hyperreactivity. Aplastic anaemia patients had significantly lower haemoglobin-adjusted diffusing capacity for carbon monoxide (DLCO) than those with leukaemia, a finding significantly related to the lower haemoglobin values shown in the former individuals. Following BMT there were transient mild to moderate reductions in DLCO and static lung volumes; moreover, patients with leukaemia had lower DLCO than those with aplastic anaemia. Fourteen of the 25 patients had ventilatory defects, including 10 individuals with bronchial hyperresponsiveness. Post-BMT lung function changes were transiently accompanied by mild to moderate symptoms of respiratory disease in most of the patients.

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Lung function in allogeneic bone marrow transplantation recipients
R Rodriguez-Roisin, J Roca, A Granena, AG Agusti, P Marin, C Rozman
European Respiratory Journal Apr 1989, 2 (4) 359-365; DOI: 10.1183/09031936.93.02040359

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Lung function in allogeneic bone marrow transplantation recipients
R Rodriguez-Roisin, J Roca, A Granena, AG Agusti, P Marin, C Rozman
European Respiratory Journal Apr 1989, 2 (4) 359-365; DOI: 10.1183/09031936.93.02040359
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