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Aspirin-intolerance as a precipitating factor of life-threatening attacks of asthma requiring mechanical ventilation

C Picado, JA Castillo, JM Montserrat, A Agusti-Vidal
European Respiratory Journal 1989 2: 127-129; DOI: 10.1183/09031936.93.02020127
C Picado
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JA Castillo
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JM Montserrat
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A Agusti-Vidal
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Abstract

The records of 92 asthmatics who underwent mechanical ventilation were reviewed. In seven patients (8%) the severe attack was precipitated by a non-steroidal anti-inflammatory drug (NSAID); one of these patients died. Five of the cases had a history of asthmatic attacks provoked by NSAIDs; whilst in two the severe attack requiring mechanical ventilation was the first manifestation of NSAID-intolerance. In two patients the NSAID had been prescribed by their physicians. Another aspirin-intolerant patient, a general practitioner, self-administered a NSAID. The sudden attack in another patient was precipitated by a preparation which contains aspirin and is usually recommended for indigestion. In the fatal case the attack was provoked by a capsule containing aspirin, which had been given by a herbalist. Unlike other reports, we found that NSAID-intolerance is a frequent provoking factor in severe acute asthma requiring mechanical ventilation. Inadequate investigation of precipitating factors in asthmatics with severe sudden attacks is a possible reason why this phenomenon is underreported.

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Aspirin-intolerance as a precipitating factor of life-threatening attacks of asthma requiring mechanical ventilation
C Picado, JA Castillo, JM Montserrat, A Agusti-Vidal
European Respiratory Journal Feb 1989, 2 (2) 127-129; DOI: 10.1183/09031936.93.02020127

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Aspirin-intolerance as a precipitating factor of life-threatening attacks of asthma requiring mechanical ventilation
C Picado, JA Castillo, JM Montserrat, A Agusti-Vidal
European Respiratory Journal Feb 1989, 2 (2) 127-129; DOI: 10.1183/09031936.93.02020127
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