Acute adrenal crisis in asthmatics treated with high-dose fluticasone propionate

Table 1—

Acute adrenal crisis-patient data

Patient	Age yrs	Sex	Clinical Presentation Blood glucose Mmol/l	Fluticasone (µg/day)/Device	Duration of Treatment (years)	Cortisol (nmol/l_ base/peak
1	33	M	Vomiting, abdominal pain, Hypotension /4.5	1000–2000 dry powder	3	69/256¹
2	7	M	Grand mal seizure /1.4	500–1000 MDI+Spacer	3	<30/41¹
3	9	F	Grand mal seizure /1.8	500–1000 MDI+Spacer	5	<70/<70²
4	7	F	Status epilepticus, Respiratory arrest / 1.3	1000–2000 Dry powder	0.5	575/600¹

MDI= metered dose inhaler
HPA axis test: ¹Short synacthen stimulation (250 µg ACTH), ²Glucagon stimulation test (500 µg i.m.)