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Acute adrenal crisis in asthmatics treated with high-dose fluticasone propionate

G.R.G. Todd, C.L. Acerini, J.J. Buck, N.P. Murphy, R. Ross-Russell, J.T. Warner, D.R. McCance
European Respiratory Journal 2002 19: 1207-1209; DOI: 10.1183/09031936.02.00274402
G.R.G. Todd
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C.L. Acerini
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J.J. Buck
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N.P. Murphy
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R. Ross-Russell
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J.T. Warner
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D.R. McCance
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Tables

  • Table 1—

    Acute adrenal crisis-patient data

    PatientAge yrsSexClinical Presentation Blood glucose Mmol/lFluticasone (µg/day)/DeviceDuration of Treatment (years)Cortisol (nmol/l_ base/peak
    133MVomiting, abdominal pain, Hypotension /4.51000–2000 dry powder369/2561
    27MGrand mal seizure /1.4500–1000 MDI+Spacer3<30/411
    39FGrand mal seizure /1.8500–1000 MDI+Spacer5<70/<702
    47FStatus epilepticus, Respiratory arrest / 1.31000–2000 Dry powder0.5575/6001
    • MDI= metered dose inhaler

    • HPA axis test: 1Short synacthen stimulation (250 µg ACTH), 2Glucagon stimulation test (500 µg i.m.)

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Acute adrenal crisis in asthmatics treated with high-dose fluticasone propionate
G.R.G. Todd, C.L. Acerini, J.J. Buck, N.P. Murphy, R. Ross-Russell, J.T. Warner, D.R. McCance
European Respiratory Journal Jun 2002, 19 (6) 1207-1209; DOI: 10.1183/09031936.02.00274402

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Acute adrenal crisis in asthmatics treated with high-dose fluticasone propionate
G.R.G. Todd, C.L. Acerini, J.J. Buck, N.P. Murphy, R. Ross-Russell, J.T. Warner, D.R. McCance
European Respiratory Journal Jun 2002, 19 (6) 1207-1209; DOI: 10.1183/09031936.02.00274402
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