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Noninvasive ventilation in cystic fibrosis patients with acute or chronic respiratory failure

B.P. Madden, H. Kariyawasam, A.J. Siddiqi, A. Machin, J.A. Pryor, M.E. Hodson
European Respiratory Journal 2002 19: 310-313; DOI: 10.1183/09031936.02.00218502
B.P. Madden
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H. Kariyawasam
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A.J. Siddiqi
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A. Machin
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J.A. Pryor
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M.E. Hodson
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    Fig. 1.—

    Computed tomography scan of the thorax of a patient with cystic fibrosis showing grossly-dilated bronchi.

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  • Table 1—

    Selection criteria for transplantation in cystic fibrosis

    Indications
     Severe respiratory failure in spite of optimal medical therapy
     Severely impaired quality of life
     Patient positively wants a transplant
    Strong contraindications
     Active aspergillus or mycobacterial infection
     Noncompliance with treatment
     Prednisolone therapy>10 mg·day−1
     Other end-organ failure
     Gross malnutrition
     HIV
     Malignancy within 5 yrs
     Hepatitis B or C
     Burkholderia cepacia Genomovar type III
     Significant osteoporosis
     Significant osteoporosis
     Drug or alcohol addiction
    Risk factors
     Pre-operative ventilation (intubated)
     Previous thoracic surgery, especially pleurectomy
     Chemical pleurodesis, especially talc
     Severe liver disease
    • HIV: human immunodeficiency virus

  • Table 2—

    Cystic fibrosis patients treated with noninvasive ventilation

    PatientsFEV1 LFVC LPa,O2 kPaPa,O2 kPaPa,CO2 kPaPa,CO2 kPa
    PrePostPrePost
    Group A (65)0.7 (63)1.4 (63)6.6 (59)8.8 (55)10.0 (59)9.0 (55)
    Group B (25)0.7 (17)1.4 (17)6.4 (20)9.9(20)9.3 (20)8.5 (20)
    Group C (23)0.6 (20)1.2 (20)7.6 (20)8.9 (21)8.5 (19)9.6 (19)
    • Data are given as median values (n=numbers of patients on whom data was available)

    • FEV1: forced expiratory volume in one second

    • FVC: forced vital capacity

    • Pa,O2: oxygen tension in arterial blood

    • Pa,CO2: carbon dioxide tension in arterial blood

Additional Files

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  • Correction

    Correction, published in Eur Respir J 2002; 20: 790.

    Files in this Data Supplement:

    • Correction - Correction, published in Eur Respir J 2002; 20: 790.
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Noninvasive ventilation in cystic fibrosis patients with acute or chronic respiratory failure
B.P. Madden, H. Kariyawasam, A.J. Siddiqi, A. Machin, J.A. Pryor, M.E. Hodson
European Respiratory Journal Feb 2002, 19 (2) 310-313; DOI: 10.1183/09031936.02.00218502

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Noninvasive ventilation in cystic fibrosis patients with acute or chronic respiratory failure
B.P. Madden, H. Kariyawasam, A.J. Siddiqi, A. Machin, J.A. Pryor, M.E. Hodson
European Respiratory Journal Feb 2002, 19 (2) 310-313; DOI: 10.1183/09031936.02.00218502
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