| Institution |
| Cornell University, USA | Hadassah University, Israel | Mayo Clinic, USA | Moffitt Cancer Center, USA | Muenster University, Germany | National Cancer Center Hospital, Japan | Shinshu University, Japan |
Inclusion Criteria | | | | | | | |
Age yrs | ≥60 | ≥50 | ≥50 | ≥45 | ≥40 | ≥50 | >40 |
Smoking history pack-yrs | ≥10 | ≥10 | ≥20 | ≥30 | ≥20 | No | ≥0 |
Fit to undergo thoracic surgery | Yes | No | Yes | Yes | No | No | No |
History of malignancy allowed | No | No | No | No | No | Yes | Yes |
Protocol design | |
Screening frequency | Annual | Annual | Annual | Annual | Annual | Biannual | Annual |
Patients at entry | 1000 | 300 | 1520 | 1150 | 1000 | Ongoing | 7847 |
Total duration yrs | Ongoing | 3 | 4 | 4 | 4 | Ongoing | 3 |
Baseline screen | |
Number of persons screened | 1000 | 619 | 1520 | 493 | 919 | 1707 | 7847 |
Number of cancers detected | 27 | 4 | 19 | 11 | 17 | 13 | 40 |
Stage I % total detected | 81 | 100 | 65 | 18 | 76 | 77 | 83 |
Annual repeat screening | |
Number of persons screened | 1184 | 50 | 1000 | 91 | ? | 9100 | 10045 |
Number of cancers detected | 7 | 0 | 2 | 0 | 2 | 21 | 40 |
Number of interval cancers | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Stage I % total detected | 85 | 0 | ? | 0 | 100 | 81 | 88 |