Figures
- Fig. 1.—
Mean Borg scores (open symbols) and forced expiratory volume in one second (FEV1; closed symbols) during the final doses of methacholine after placebo (squares), or pretreatment with salmeterol (circles) or formoterol (triangles).
Tables
- Table 1—
Characteristics of the patients at enrolment.
F/M 15/4 Age yrs 38±7 (24–49) FEV1 L 2.88±0.66 (1.74–3.98) FEV1 % of pred 88.4±16.1 (63–111) PC20 methacholine mg·mL−1 0.62 (0.06–4.3) Inhaled steroid dose µg·day−1 500 (400–1600) Data are presented as absolute numbers or as mean±sd (range), except provocative concentration of methacholine causing forced expiratory volume in one second (FEV1) to fall by 20% (PC20) and steroid dose where median (range) is given
M: male
F: female
- Table 2—
forced expiratory volume in one second FEV1 and Borg score at baseline and at reaching a methacholine induced ≥30% fall in FEV1
Subjects n Baseline FEV1 FEV1 after methacholine Baseline Borg score Borg score after methacholine PD30+ Dyspnoea perception Formoterol 17 2.99±0.74 1.73±0.52 0.4±0.7 2.65±1.44 12.4 mg 0.067±0.040 (−42.2±8.3%) 0.0 (0–2) 3.0 (0.5–5) Salmeterol 16 2.98±0.73 1.83±0.56 0.4 ±0.6 2.78±1.37 7.9 mg 0.076±0.040 (−38.4±9.5%) 0.0 (0–2) 3.0 (0.5–4) Placebo 16 2.67±0.65 1.68±0.46 0.6±0.6 2.66±1.25 3.7 mg 0.074±0.036 (−37.0±5.8%) 0.5 (0–2) 3.0 (0.5–5) Data are presented as mean±sd
Borg score also as median (range)
Dyspnoea perception is presented as %−1. Baseline represents the value one hour after inhaling the last dose of study medication
PD30+: cumulative dose of methacholine administered at ≥30% fall in FEV1 (geometric mean)
