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Variations in the prevalence across countries of chronic bronchitis and smoking habits in young adults

I. Cerveri, S. Accordini, G. Verlato, A. Corsico, M.C. Zoia, L. Casali, P. Burney, R. de Marco for the European Community Respiratory Health Survey (ECRHS) Study Group
European Respiratory Journal 2001 18: 85-92; DOI: 10.1183/09031936.01.00087101
I. Cerveri
1Institute of Respiratory Disease, IRCCS Policlinico S. Matteo, University of Pavia and 2Unit of Epidemiology and Medical Statistics, University of Verona, Italy. 3Dept of Public Health Sciences, King's College, Guy's Hospital, London, UK
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S. Accordini
1Institute of Respiratory Disease, IRCCS Policlinico S. Matteo, University of Pavia and 2Unit of Epidemiology and Medical Statistics, University of Verona, Italy. 3Dept of Public Health Sciences, King's College, Guy's Hospital, London, UK
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G. Verlato
1Institute of Respiratory Disease, IRCCS Policlinico S. Matteo, University of Pavia and 2Unit of Epidemiology and Medical Statistics, University of Verona, Italy. 3Dept of Public Health Sciences, King's College, Guy's Hospital, London, UK
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A. Corsico
1Institute of Respiratory Disease, IRCCS Policlinico S. Matteo, University of Pavia and 2Unit of Epidemiology and Medical Statistics, University of Verona, Italy. 3Dept of Public Health Sciences, King's College, Guy's Hospital, London, UK
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M.C. Zoia
1Institute of Respiratory Disease, IRCCS Policlinico S. Matteo, University of Pavia and 2Unit of Epidemiology and Medical Statistics, University of Verona, Italy. 3Dept of Public Health Sciences, King's College, Guy's Hospital, London, UK
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L. Casali
1Institute of Respiratory Disease, IRCCS Policlinico S. Matteo, University of Pavia and 2Unit of Epidemiology and Medical Statistics, University of Verona, Italy. 3Dept of Public Health Sciences, King's College, Guy's Hospital, London, UK
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P. Burney
1Institute of Respiratory Disease, IRCCS Policlinico S. Matteo, University of Pavia and 2Unit of Epidemiology and Medical Statistics, University of Verona, Italy. 3Dept of Public Health Sciences, King's College, Guy's Hospital, London, UK
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R. de Marco
1Institute of Respiratory Disease, IRCCS Policlinico S. Matteo, University of Pavia and 2Unit of Epidemiology and Medical Statistics, University of Verona, Italy. 3Dept of Public Health Sciences, King's College, Guy's Hospital, London, UK
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1Institute of Respiratory Disease, IRCCS Policlinico S. Matteo, University of Pavia and 2Unit of Epidemiology and Medical Statistics, University of Verona, Italy. 3Dept of Public Health Sciences, King's College, Guy's Hospital, London, UK
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  • Fig. 1.—
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    Fig. 1.—

    Prevalence of chronic bronchitis plotted by country and centre. Each symbol represents the value for one centre. Countries are ordered along the abscissa by increasing values of the median within each country. The dotted line indicates the median of the prevalences. Values significantly above or below the median for 35 centres are indicated. □: 95% confidence interval (CI) below and excludes study median; ▵ 95% CI includes study median; ○: 95% CI above and excludes study median. UK: United Kingdom; Fr: France; Au: Australia; Ic: Iceland; Swi: Switzerland; No: Norway; NL: the Netherlands; Swe: Sweden; NZ: New Zealand; It: Italy; Ge: Germany; Be: Belgium; De: Denmark; USA: United States of America; Ir: Ireland; Sp: Spain.

  • Fig. 2.—
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    Fig. 2.—

    Prevalence of current smokers plotted by country and centre. Each symbol represents the value for one centre. Countries are ordered along the abscissa by increasing values of the median of the prevalences of chronic bronchitis within each country. The dotted line indicates the median of the prevalences of current smokers. Values significantly above or below the median for 35 centres are indicated. □: 95% confidence interval (CI) below and excludes study median; ▵ 95% CI includes study median; ○: 95% CI above and excludes study median. UK: United Kingdom; Fr: France; Au: Australia; Ic: Iceland; Swi: Switzerland; No: Norway; NL: the Netherlands; Swe: Sweden; NZ: New Zealand; It: Italy; Ge: Germany; Be: Belgium; De: Denmark; USA: United States of America; Ir: Ireland; Sp: Spain.

  • Fig. 3.—
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    Fig. 3.—

    Forced expiratory volume in one second (FEV1) % predicted in a) males and b) females, plotted according to chronic bronchitis and smoking habits. □: without chronic bronchitis; └: with chronic bronchitis.

Tables

  • Figures
  • Table 1

    Number of subjects randomly selected for the European Community Respiratory Health Survey (ECRHS)-stage 2, number (%) of responders to questions on asthma and bronchitis, and number (%) of subjects with at least two technically acceptable measurements of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC)

    Center (Country)Subjects selected for ECRHS-stage 2Subjects filling in the questionnaireSubjects with reliable FEV1 and FVC measurement
    nn%n%
    Antwerp South (Belgium)80055569.436265.2
    Antwerp City (Belgium)86756064.633559.8
    Aarhus (Denmark)65236355.729079.9
    Hamburg (Germany)3312125137.8100880.6
    Erfurt (Germany)107672167.062987.2
    Barcelona (Spain)53439373.620752.7
    Galdakao (Spain)57648684.438679.4
    Albacete (Spain)65843566.141695.6
    Oviedo (Spain)52235568.025471.5
    Huelva (Spain)47827156.724991.9
    Bordeaux (France)293653918.442979.6
    Grenoble (France)116548441.546696.3
    Montpellier (France)373645112.144298.0
    Paris (France)311364820.857488.6
    Dublin (Ireland)59941168.629571.8
    Pavia (Italy)81628434.823582.7
    Turin (Italy)51824346.920885.6
    Verona (Italy)50435470.231689.3
    Groningen (The Netherlands)59942571.040695.5
    Bergen-op-Zoom (The Netherlands)63849677.748197.0
    Geleen (The Netherlands)67143665.040192.0
    Cambridge (UK)52727452.021879.6
    Ipswich (UK)68239958.538295.7
    Norwich (UK)65546070.236078.3
    Reykjavik (Iceland)67256483.952893.6
    Bergen (Norway)969969100.088190.9
    Goteborg (Sweden)77268288.359086.5
    Umea (Sweden)61155190.246584.4
    Uppsala (Sweden)70960885.847578.1
    Basel (Switzerland)121084469.874888.6
    Wellington (New Zealand)74147063.434473.2
    Christchurch (New Zealand)71244963.132572.4
    Hawkes Bay (New Zealand)54931457.218960.2
    Portland (USA)160455334.537367.5
    Melbourne (Australia)164466840.655282.6
    Total368271796648.81481982.5
    • % are computed using people selected for random sample as reference

    • % are computed using people filling in the questionnaire as reference

  • Table 2

    Prevalence of current smokers and past smokers by sex and country in people attending the European Community Respiratory Health Survey (ECRHS)-stage 2

    CountryCurrent smokers %Past smokers %
    MalesFemalesMalesFemales
    Belgium40.5 (36.1–45.0)31.5 (27.9–35.3)18.7 (15.4–22.5)24.0 (20.7–27.5)
    Denmark40.8 (32.9–49.0)41.6 (34.7–48.7)18.4 (12.6–25.5)12.4 (8.2–17.7)
    Germany47.8 (44.7–50.9)39.7 (36.6–42.9)22.8 (20.2–25.5)22.5 (19.9–25.3)
    Spain58.6 (55.3–61.7)44.3 (41.2–47.4)14.1 (12.0–16.5)14.5 (12.4–16.9)
    France38.3 (35.3–41.3)32.0 (29.2–34.9)24.6 (22.1–27.4)24.1 (21.6–26.8)
    Ireland44.2 (37.3–51.2)46.5 (39.5–53.7)18.4 (13.4–24.4)13.9 (9.4–19.4)
    Italy42.8 (38.1–47.6)30.1 (25.8–34.6)20.0 (16.4–24.1)18.6 (15.0–22.5)
    The Netherlands44.3 (40.4–48.2)39.1 (35.4–42.9)20.0 (17.0–23.3)23.1 (19.9–26.4)
    UK28.3 (24.3–32.5)25.9 (22.5–29.5)24.6 (20.8–28.6)18.4 (15.5–21.6)
    Iceland42.0 (36.1–48.1)38.3 (32.7–44.1)25.2 (20.2–30.8)20.3 (15.9–25.4)
    Norway46.1 (41.6–50.7)43.3 (38.8–47.9)13.5 (10.6–16.8)17.2 (13.9–20.8)
    Sweden26.2 (23.3–29.2)31.0 (28.1–34.1)23.6 (20.9–26.5)21.7 (19.1–24.5)
    Switzerland41.2 (36.5–46.1)40.2 (35.5–45.1)19.2 (15.5–23.3)17.3 (13.8–21.3)
    New Zealand21.8 (18.4–25.6)23.7 (20.4–27.4)24.3 (20.7–28.1)24.2 (20.9–27.9)
    USA23.5 (18.1–29.7)17.8 (13.8–22.3)19.9 (14.9–25.8)21.7 (17.4–26.5)
    Australia26.8 (22.0–32.0)22.3 (18.0–27.0)25.2 (20.6–30.4)27.7 (23.1–32.8)
    • Data are presented as prevalence rates (%) with 95% confidence interval in parentheses

  • Table 3

    Distribution of smoking habits in both sexes by the presence of chronic bronchitis

    Smoking habits〈Males***〉〈Females***〉〈Total***〉
    With chronic bronchitisWithout chronic bronchitisWith chronic bronchitisWithout chronic bronchitisWith chronic bronchitisWithout chronic bronchitis
    Nonsmokers43 (13.4%)3332 (40.4%)55 (21.6%)4101 (45.7%)98 (17.0%)7433 (43.1%)
    Past smokers30 (9.3%)1767 (21.4%)26 (10.2%)1886 (21.0%)56 (9.7%)3653 (21.2%)
    Current smokers248 (77.3%)3148 (38.2%)174 (68.2%)2992 (33.3%)422 (73.3%)6140 (35.6%)
    1–14 pack-yrs71 (22.1%)1537 (18.6%)80 (31.4%)1906 (21.2%)151 (26.2%)3443 (20.0%)
    15–29 pack-yrs81 (25.2%)941 (11.4%)52 (20.4%)753 (8.4%)133 (23.1%)1694 (9.8%)
    30–44 pack-yrs48 (15.0%)297 (3.6%)24 (9.4%)175 (1.9%)72 (12.5%)472 (2.7%)
    ≥45 pack-yrs33 (10.3%)120 (1.5%)9 (3.5%)53 (0.6%)42 (7.3%)173 (1.0%)
    Unknown15 (4.7%)253 (3.1%)9 (3.5%)105 (1.2%)24 (4.2%)358 (2.1%)
    Total3218247255897957617226
    • Data are presented as n (%). Some subjects (n=164) did not answer questions on smoking habits

    • ***: p<0.001, the distribution of smoking habits varied significantly between subjects with and without chronic bronchitis in both sexes and in the total sample

  • Table 4

    Adjusted odds ratios (OR), 95% confidence intervals (95% CI) and p-values for the effect of smoking habits, respiratory infection before the age of 5 yrs, occupational exposure and socioeconomic status on chronic bronchitis

    〈Males〉〈Females〉
    OR95% CIOR95% CI
    Smoking habits#
     Past smoker1.380.84–2.261.080.67–1.72
     Current smoker (1–14 pack-yrs)3.51***2.31–5.323.06***2.13–44.0
     Current smoker (15–29 pack-yrs)6.32***4.20–9.525.02***3.36–7.48
     Current smoker (30–44 pack-yrs)12.13***7.57–19.468.47***4.89–14.65
     Current smoker (≥45 pack-yrs)17.32***9.97–30.1110.63***4.69–24.13
    Respiratory infection before the age of 5 yrs
     Yes versus no0.900.57–1.411.400.95–2.07
    Occupational exposure
     Yes versos no1.49*1.12–1.981.66***1.26–2.18
    Socioeconomic status
     Low versus high1.35*1.01–1.811.080.79–1.48
    • #: versus nonsmokers

    • The ORs were calculated by a multilevel logistic regression model with random intercept at the level of the European Community Respiratory Health Survey (ECRHS) centre and all predictor variables as fixed effects. The ORs were also adjusted for the effect of the percentage of responders to questions on asthma and bronchitis in each ECRHS centre

    • *: p<0.05

    • ***: p<0.001

    • p-values for the main factors were determined using the wald test

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Variations in the prevalence across countries of chronic bronchitis and smoking habits in young adults
I. Cerveri, S. Accordini, G. Verlato, A. Corsico, M.C. Zoia, L. Casali, P. Burney, R. de Marco
European Respiratory Journal Jul 2001, 18 (1) 85-92; DOI: 10.1183/09031936.01.00087101

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Variations in the prevalence across countries of chronic bronchitis and smoking habits in young adults
I. Cerveri, S. Accordini, G. Verlato, A. Corsico, M.C. Zoia, L. Casali, P. Burney, R. de Marco
European Respiratory Journal Jul 2001, 18 (1) 85-92; DOI: 10.1183/09031936.01.00087101
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