Isotype switching of B cells from immunoglobulins G to E synthesis |
Differentiation/proliferation Th2 cells |
Inhibition development Th1 cells |
Upregulation FcεRII and major histocompatibility complex Class II antigen expression on Antigen Presenting Cells |
Upregulation endothelial vascular cell adhesion molecule‐1 expression |
Downregulation endothelial intercellular adhesion molecule‐1 expression |
Downregulation production of pro-inflammatory cytokines (tumour necrosis factor α, interleukin 1β) and chemokines (regulated on activation, normal T cell expressed and secreted, interleukin‐8) |
Promoting growth of human basophils and eosinophils |
Chemotaxis and activation of fibroblasts |
Stimulation of mucus production |