Tables
- Table 1—
The clinical characteristics of the study participants
≥1×105 cfu·mL−1 <1×105 cfu·mL−1 Subjects n 9 24 Age months 35.3±21.3 22.1±13.3 Age range months 3–57 1.5–50 Sex % male 33 54 CF genotype % Homozygous ΔF508 7 (78) 16 (67) Heterozygous ΔF508 1 (11) 7 (29) No copies ΔF508 1 (11) 1 (4) Respiratory symptoms % 8 (89) 19 (79) Oral antibiotics % 6 (67) 12 (50) Data are presented as mean±sd or n (%).
1×105 colony forming units of pathogenic bacteria·mL−1 of bronchoalveolar lavage fluid from ≥1 lobes 9
oral antistaphylococcal antibiotics. CF: cyctic fibrosis.
- Table 2—
Cystic fibrosis subjects with ≥1×105 cfu·mL−1 of bacteria in their bronchalveolar lavage
Nature of infection Subject number Age months Sex Lobe BAL order Pathogen cfu.mL−1 % n# IL-8 pg.mL−1 Focal 1 55 F RML 1st M. catarrhalis 1×108 70 217 Lingula 2nd M. catarrhalis 1×104 73 135 2 52 F RML 2nd B. cepacia 1×105 50 5968 H. influenzae 1×104 S. aureus 1×103 P. aeruginosa 1×102 Lingula 1st H. influenzae 1×102 43 1417 3 35 F RML 1st M. catarrhalis 1×105 56 6300 Lingula 2nd No pathogens — 62 1493 4 24 M RML 2nd S. aureus 1×106 77 362 Lingula 1st S. aureus 1×104 17 878 5 3 M RML 2nd S. aureus 1×105 69 1587 Lingula 1st S. aureus 1×101 24 2922 6 37 F RML 2nd P. aeruginosa 1×105 80 389 Lingula 1st P. aeruginosa 1×104 95 757 Bilateral 7 57 M RML 2nd P. aeruginosa 1×108 51 1672 Lingula 1st P. aeruginosa 1×107 67 1436 8 52 F RML 2nd P. aeruginosa 1×107 85 9805 Lingula 1st P. aeruginosa 1×106 91 4908 9 3 F RML 1st M. catarrhalis 1×106 51 372 Lingula 2nd M. catarrhalis 1×105 50 442 Colony forming units·mL−1 of bronchoalveolar lavage (BAL) fluid
percentage neutrophils. RML: right middle lobe; IL-8: interleukin-8
- Table 3—
Cystic fibrosis infant bronchoalveolar lavage profiles from the right middle and lingula lobes
≥1×105 cfu·mL−1 <1×105 cfu·mL−1 in both lobes RML p-value Lingula RML Lingula Subjects n 6 24 Recovery % 34 0.88 32 41 44 CI 19–58 — 23–45 34–50 36–51 p-value 0.42 — 0.09 Pathogen cfu·mL−1 4.6×105 0.003 3.2×102 2.6×101 2.1×101 CI 2.5–86 — 0.04–22.3 0.4–11.6 0.3–7.8 p-value <0.001 — 0.15 — — Total cell count ×104·mL−1 171 0.09 106 136 120 CI 124–260 — 42–265 100–184 83–172 p-value 0.19 — 0.77 — — Macrophages % 30 0.29 44 68 66 CI 27–43 — 12–75 59–76 59–74 p-value <0.001 — 0.14 — — Neutrophils % 67 0.29 52 28 29 CI 55–79 — 21–84 21–35 22–36 p-value <0.001 — 0.12 — — Lymphocytes % 4.0 0.85 3.8 3.0 3.2 CI 0.4–7.6 — 0.4–7.2 1.9–4.0 2.3–4.0 p-value 0.51 — 0.65 — — IL-8 pg·mL−1 1104 0.67 906 229 175 CI 233–5236 302–2716 114–459 108–283 p-value 0.05 0.01 — — ≥1×105 cfu·mL−1 in the right middle lobe only
paired t-test between right middle and lingula lobes in the 6 subjects with ≥1×105 cfu·mL−1 in the right middle lobe only
2-sample t-test between right middle lobes and between lingula lobes in the 6 subjects with unilateral (right middle lobe only) bacterial counts ≥1×105 cfu·mL−1 and the 24 subjects with 1×105 cfu·mL−1 in both lobes. IL-8: interleukin-8
