Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Effect of chronic hypoxia on calcium signalling in airway smooth muscle cells

NE Belouchi, E Roux, JP Savineau, R Marthan
European Respiratory Journal 1999 14: 74-79; DOI:
NE Belouchi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
E Roux
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
JP Savineau
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R Marthan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • PDF
Loading

Abstract

Chronic hypoxia (CH) alters smooth muscle contractility. CH generally produces a sustained attenuation of vasoreactivity. In airways, this effect of CH is poorly understood although CH is frequently observed in patients with pulmonary diseases. This study was designed to examine the effect of CH on both the isometric contraction of isolated rings and the cytosolic calcium concentration ([Ca2+]i) using microspectrofluorimetry in freshly isolated cells from rat tracheal smooth muscle. Tissues were obtained from both chronically hypoxic rats maintained in a hypobaric chamber (50.5 kPa) for 15 days and normoxic animals. CH increased the sensitivity of airway smooth muscle to cholinergic agonists. This increase observed in the mechanical activity (concentration of carbachol producing 50% of the maximal force (EC50) in tissues from normoxic and hypoxic animals: 0.80 microM (0.39-1.21 microM) and 0.34 microM (0.08-0.59 microM), respectively, p<0.05) was related to an increase in the sensitivity of cholinergic-mediated Ca2+ release (acetylcholine EC50 in cells from normoxic and hypoxic animals: 0.14 microM (0.11-0.17 microM) and 0.04 microM (0.026-0.054 microM), respectively, p<0.05). It was concluded that chronic hypoxia alters calcium signalling in airway smooth muscle cells, which was associated with an increase in airway responsiveness in vitro. Whether a similar phenomenon contributes to bronchial hyperresponsiveness in chronically hypoxaemic patients remains to be established.

PreviousNext
Back to top
Vol 14 Issue 1 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Effect of chronic hypoxia on calcium signalling in airway smooth muscle cells
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Effect of chronic hypoxia on calcium signalling in airway smooth muscle cells
NE Belouchi, E Roux, JP Savineau, R Marthan
European Respiratory Journal Jul 1999, 14 (1) 74-79;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Effect of chronic hypoxia on calcium signalling in airway smooth muscle cells
NE Belouchi, E Roux, JP Savineau, R Marthan
European Respiratory Journal Jul 1999, 14 (1) 74-79;
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Ambulatory management of secondary spontaneous pneumothorax
  • Systematic assessment of respiratory health in illness susceptible athletes
  • Identifying early PAH biomarkers in systemic sclerosis
Show more Original Articles

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2022 by the European Respiratory Society