Mechanisms of lung disease

Towards an artificial human lung: modelling organ-like complexity to aid mechanistic understanding
Maria Victoria Humbert, Cosma Mirella Spalluto, Joseph Bell, Cornelia Blume, Franco Conforti, Elizabeth R. Davies, Lareb S.N. Dean, Paul Elkington, Hans Michael Haitchi, Claire Jackson, Mark G. Jones, Matthew Loxham, Jane S. Lucas, Hywel Morgan, Marta Polak, Karl J. Staples, Emily J. Swindle, Liku Tezera, Alastair Watson, Tom M.A. Wilkinson

European Respiratory Journal Dec 2022, 60 (6) 2200455; DOI: 10.1183/13993003.00455-2022
Neuropeptide regulation of secretion and inflammation in human airway gland serous cells
Derek B. McMahon, Ryan M. Carey, Michael A. Kohanski, Charles C.L. Tong, Peter Papagiannopoulos, Nithin D. Adappa, James N. Palmer, Robert J. Lee

European Respiratory Journal Apr 2020, 55 (4) 1901386; DOI: 10.1183/13993003.01386-2019
Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension
Catherine E. Simpson, Jenny Y. Chen, Rachel L. Damico, Paul M. Hassoun, Lisa J. Martin, Jun Yang, Melanie Nies, Megan Griffiths, Dhananjay Vaidya, Stephanie Brandal, Michael W. Pauciulo, Katie A. Lutz, Anna W. Coleman, Eric D. Austin, Dunbar D. Ivy, William C. Nichols, Allen D. Everett

European Respiratory Journal Apr 2020, 55 (4) 1901761; DOI: 10.1183/13993003.01761-2019
Lipids and ketones dominate metabolism at the expense of glucose control in pulmonary arterial hypertension: a hyperglycaemic clamp and metabolomics study
Jacob T. Mey, Adithya Hari, Christopher L. Axelrod, Ciarán E. Fealy, Melissa L. Erickson, John P. Kirwan, Raed A. Dweik, Gustavo A. Heresi

European Respiratory Journal Apr 2020, 55 (4) 1901700; DOI: 10.1183/13993003.01700-2019
Familial pulmonary arterial hypertension by KDR heterozygous loss of function
Mélanie Eyries, David Montani, Barbara Girerd, Nicolas Favrolt, Marianne Riou, Laurence Faivre, Grégoire Manaud, Frédéric Perros, Stefan Gräf, Nicholas W. Morrell, Marc Humbert, Florent Soubrier

European Respiratory Journal Apr 2020, 55 (4) 1902165; DOI: 10.1183/13993003.02165-2019
The NLRP3 inflammasome pathway is activated in sarcoidosis and involved in granuloma formation
Christine Huppertz, Benedikt Jäger, Grazyna Wieczorek, Peggy Engelhard, Stephen J. Oliver, Franz-Georg Bauernfeind, Amanda Littlewood-Evans, Tobias Welte, Veit Hornung, Antje Prasse

European Respiratory Journal Mar 2020, 55 (3) 1900119; DOI: 10.1183/13993003.00119-2019
Culture of pulmonary artery endothelial cells from pulmonary artery catheter balloon tips: considerations for use in pulmonary vascular disease
Corey E. Ventetuolo, Jason M. Aliotta, Julie Braza, Havovi Chichger, Mark Dooner, Donald McGuirl, Christopher J. Mullin, Julie Newton, Mandy Pereira, Amy Princiotto, Peter J. Quesenberry, Thomas Walsh, Mary Whittenhall, James R. Klinger, Elizabeth O. Harrington

European Respiratory Journal Mar 2020, 55 (3) 1901313; DOI: 10.1183/13993003.01313-2019
Connexin-43 is a promising target for pulmonary hypertension due to hypoxaemic lung disease
Claire Bouvard, Nafiisha Genet, Carole Phan, Baptiste Rode, Raphaël Thuillet, Ly Tu, Paul Robillard, Marilyne Campagnac, Raffaella Soleti, Eric Dumas De La Roque, Frédéric Delcambre, Laurent Cronier, Thibaud Parpaite, Elise Maurat, Patrick Berger, Jean-Pierre Savineau, Roger Marthan, Christophe Guignabert, Véronique Freund-Michel, Christelle Guibert

European Respiratory Journal Mar 2020, 55 (3) 1900169; DOI: 10.1183/13993003.00169-2019
Morphomolecular motifs of pulmonary neoangiogenesis in interstitial lung diseases
Maximilian Ackermann, Helge Stark, Lavinia Neubert, Stephanie Schubert, Paul Borchert, Friedemann Linz, Willi L. Wagner, Wolfram Stiller, Mark Wielpütz, Anne Hoefer, Axel Haverich, Steven J. Mentzer, Harshit R. Shah, Tobias Welte, Mark Kuehnel, Danny Jonigk

European Respiratory Journal Mar 2020, 55 (3) 1900933; DOI: 10.1183/13993003.00933-2019
The mucus bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation
Anna Ermund, Lauren N. Meiss, Brendan Dolan, Andrea Bähr, Nikolai Klymiuk, Gunnar C. Hansson

European Respiratory Journal Aug 2018, 52 (2) 1800457; DOI: 10.1183/13993003.00457-2018

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