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Genetics

  • Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection
    Richard J. Packer, Nick Shrine, Robert Hall, Carl A. Melbourne, Rebecca Thompson, Alex T. Williams, Megan L. Paynton, Anna L. Guyatt, Richard J. Allen, Paul H. Lee, Catherine John, Archie Campbell, Caroline Hayward, Maaike de Vries, Judith M. Vonk, Jonathan Davitte, Edith Hessel, David Michalovich, Joanna C. Betts, Ian Sayers, Astrid Yeo, Ian P. Hall, Martin D. Tobin, Louise V. Wain
    European Respiratory Journal Jun 2023, 61 (6) 2201667; DOI: 10.1183/13993003.01667-2022
  • Utility of whole genome sequencing in assessing risk and clinically relevant outcomes for pulmonary fibrosis
    David Zhang, Chad A. Newton, Binhan Wang, Gundula Povysil, Imre Noth, Fernando J. Martinez, Ganesh Raghu, David Goldstein, Christine Kim Garcia
    European Respiratory Journal Dec 2022, 60 (6) 2200577; DOI: 10.1183/13993003.00577-2022
  • A polygenic risk score and age of diagnosis of COPD
    Jingzhou Zhang, Hanfei Xu, Dandi Qiao, Dawn L. DeMeo, Edwin K. Silverman, George T. O'Connor, Brian D. Hobbs, Josée Dupuis, Michael H. Cho, Matthew Moll
    European Respiratory Journal Sep 2022, 60 (3) 2101954; DOI: 10.1183/13993003.01954-2021
  • Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension
    Mark Toshner, Colin Church, Lars Harbaum, Christopher Rhodes, Sofia S. Villar Moreschi, James Liley, Rowena Jones, Amit Arora, Ken Batai, Ankit A. Desai, John G. Coghlan, J. Simon R. Gibbs, Dee Gor, Stefan Gräf, Louise Harlow, Jules Hernandez-Sanchez, Luke S. Howard, Marc Humbert, Jason Karnes, David G. Kiely, Rick Kittles, Emily Knightbridge, Brian Lam, Katie A. Lutz, William C. Nichols, Michael W. Pauciulo, Joanna Pepke-Zaba, Jay Suntharalingam, Florent Soubrier, Richard C. Trembath, Tae-Hwi L. Schwantes-An, S. John Wort, Martin R. Wilkins, Sean Gaine, Nicholas W. Morrell, Paul A. Corris
    European Respiratory Journal Mar 2022, 59 (3) 2002463; DOI: 10.1183/13993003.02463-2020
  • Genetically increased circulating FUT3 level leads to reduced risk of idiopathic pulmonary fibrosis: a Mendelian randomisation study
    Tomoko Nakanishi, Agustin Cerani, Vincenzo Forgetta, Sirui Zhou, Richard J. Allen, Olivia C. Leavy, Masaru Koido, Deborah Assayag, R. Gisli Jenkins, Louise V. Wain, Ivana V. Yang, G. Mark Lathrop, Paul J. Wolters, David A. Schwartz, J. Brent Richards
    European Respiratory Journal Feb 2022, 59 (2) 2003979; DOI: 10.1183/13993003.03979-2020
  • Associations of genetic risk and smoking with incident COPD
    Pei-Dong Zhang, Xi-Ru Zhang, Ao Zhang, Zhi-Hao Li, Dan Liu, Yu-Jie Zhang, Chen Mao
    European Respiratory Journal Feb 2022, 59 (2) 2101320; DOI: 10.1183/13993003.01320-2021
  • A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity
    Zhaozhong Zhu, Jiachen Li, Jiahui Si, Baoshan Ma, Huwenbo Shi, Jun Lv, Weihua Cao, Yu Guo, Iona Y. Millwood, Robin G. Walters, Kuang Lin, Ling Yang, Yiping Chen, Huaidong Du, Bo Yu, Kohei Hasegawa, Carlos A. Camargo, Miriam F. Moffatt, William O.C. Cookson, Junshi Chen, Zhengming Chen, Liming Li, Canqing Yu, Liming Liang
    European Respiratory Journal Oct 2021, 58 (4) 2100199; DOI: 10.1183/13993003.00199-2021
  • Maternal 17q21 genotype influences prenatal vitamin D effects on offspring asthma/recurrent wheeze
    Hanna M. Knihtilä, Rachel S. Kelly, Nicklas Brustad, Mengna Huang, Priyadarshini Kachroo, Bo L. Chawes, Jakob Stokholm, Klaus Bønnelykke, Casper-Emil T. Pedersen, Hans Bisgaard, Augusto A. Litonjua, Jessica A. Lasky-Su, Scott T. Weiss
    European Respiratory Journal Sep 2021, 58 (3) 2002012; DOI: 10.1183/13993003.02012-2020
  • Lung function and cardiovascular disease: a two-sample Mendelian randomisation study
    Daniel H. Higbee, Raquel Granell, Eleanor Sanderson, George Davey Smith, James W. Dodd
    European Respiratory Journal Sep 2021, 58 (3) 2003196; DOI: 10.1183/13993003.03196-2020
  • Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use
    Natalia Hernandez-Pacheco, Susanne J. Vijverberg, Esther Herrera-Luis, Jiang Li, Yang Yie Sio, Raquel Granell, Almudena Corrales, Cyrielle Maroteau, Ryan Lethem, Javier Perez-Garcia, Niloufar Farzan, Katja Repnik, Mario Gorenjak, Patricia Soares, Leila Karimi, Maximilian Schieck, Lina Pérez-Méndez, Vojko Berce, Roger Tavendale, Celeste Eng, Olaia Sardon, Inger Kull, Somnath Mukhopadhyay, Munir Pirmohamed, Katia M.C. Verhamme, Esteban G. Burchard, Michael Kabesch, Daniel B. Hawcutt, Erik Melén, Uroš Potočnik, Fook Tim Chew, Kelan G. Tantisira, Steve Turner, Colin N. Palmer, Carlos Flores, Maria Pino-Yanes, Anke H. Maitland-van der Zee
    European Respiratory Journal May 2021, 57 (5) 2003388; DOI: 10.1183/13993003.03388-2020

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