Genetics

  • Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension
    Mark Toshner, Colin Church, Lars Harbaum, Christopher Rhodes, Sofia S. Villar Moreschi, James Liley, Rowena Jones, Amit Arora, Ken Batai, Ankit A. Desai, John G. Coghlan, J. Simon R. Gibbs, Dee Gor, Stefan Gräf, Louise Harlow, Jules Hernandez-Sanchez, Luke S. Howard, Marc Humbert, Jason Karnes, David G. Kiely, Rick Kittles, Emily Knightbridge, Brian Lam, Katie A. Lutz, William C. Nichols, Michael W. Pauciulo, Joanna Pepke-Zaba, Jay Suntharalingam, Florent Soubrier, Richard C. Trembath, Tae-Hwi L. Schwantes-An, S. John Wort, Martin R. Wilkins, Sean Gaine, Nicholas W. Morrell, Paul A. Corris
    European Respiratory Journal Mar 2022, 59 (3) 2002463; DOI: 10.1183/13993003.02463-2020
  • Associations of genetic risk and smoking with incident COPD
    Pei-Dong Zhang, Xi-Ru Zhang, Ao Zhang, Zhi-Hao Li, Dan Liu, Yu-Jie Zhang, Chen Mao
    European Respiratory Journal Feb 2022, 59 (2) 2101320; DOI: 10.1183/13993003.01320-2021
  • Genetically increased circulating FUT3 level leads to reduced risk of idiopathic pulmonary fibrosis: a Mendelian randomisation study
    Tomoko Nakanishi, Agustin Cerani, Vincenzo Forgetta, Sirui Zhou, Richard J. Allen, Olivia C. Leavy, Masaru Koido, Deborah Assayag, R. Gisli Jenkins, Louise V. Wain, Ivana V. Yang, G. Mark Lathrop, Paul J. Wolters, David A. Schwartz, J. Brent Richards
    European Respiratory Journal Feb 2022, 59 (2) 2003979; DOI: 10.1183/13993003.03979-2020
  • A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic aetiology with obesity
    Zhaozhong Zhu, Jiachen Li, Jiahui Si, Baoshan Ma, Huwenbo Shi, Jun Lv, Weihua Cao, Yu Guo, Iona Y. Millwood, Robin G. Walters, Kuang Lin, Ling Yang, Yiping Chen, Huaidong Du, Bo Yu, Kohei Hasegawa, Carlos A. Camargo, Miriam F. Moffatt, William O.C. Cookson, Junshi Chen, Zhengming Chen, Liming Li, Canqing Yu, Liming Liang
    European Respiratory Journal Oct 2021, 58 (4) 2100199; DOI: 10.1183/13993003.00199-2021
  • Maternal 17q21 genotype influences prenatal vitamin D effects on offspring asthma/recurrent wheeze
    Hanna M. Knihtilä, Rachel S. Kelly, Nicklas Brustad, Mengna Huang, Priyadarshini Kachroo, Bo L. Chawes, Jakob Stokholm, Klaus Bønnelykke, Casper-Emil T. Pedersen, Hans Bisgaard, Augusto A. Litonjua, Jessica A. Lasky-Su, Scott T. Weiss
    European Respiratory Journal Sep 2021, 58 (3) 2002012; DOI: 10.1183/13993003.02012-2020
  • Lung function and cardiovascular disease: a two-sample Mendelian randomisation study
    Daniel H. Higbee, Raquel Granell, Eleanor Sanderson, George Davey Smith, James W. Dodd
    European Respiratory Journal Sep 2021, 58 (3) 2003196; DOI: 10.1183/13993003.03196-2020
  • Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use
    Natalia Hernandez-Pacheco, Susanne J. Vijverberg, Esther Herrera-Luis, Jiang Li, Yang Yie Sio, Raquel Granell, Almudena Corrales, Cyrielle Maroteau, Ryan Lethem, Javier Perez-Garcia, Niloufar Farzan, Katja Repnik, Mario Gorenjak, Patricia Soares, Leila Karimi, Maximilian Schieck, Lina Pérez-Méndez, Vojko Berce, Roger Tavendale, Celeste Eng, Olaia Sardon, Inger Kull, Somnath Mukhopadhyay, Munir Pirmohamed, Katia M.C. Verhamme, Esteban G. Burchard, Michael Kabesch, Daniel B. Hawcutt, Erik Melén, Uroš Potočnik, Fook Tim Chew, Kelan G. Tantisira, Steve Turner, Colin N. Palmer, Carlos Flores, Maria Pino-Yanes, Anke H. Maitland-van der Zee
    European Respiratory Journal May 2021, 57 (5) 2003388; DOI: 10.1183/13993003.03388-2020
  • DNA methylation at birth is associated with lung function development until age 26 years
    Nandini Mukherjee, Ryan Arathimos, Su Chen, Parnian Kheirkhah Rahimabad, Luhang Han, Hongmei Zhang, John W. Holloway, Caroline Relton, A. John Henderson, Syed Hasan Arshad, Susan Ewart, Wilfried Karmaus
    European Respiratory Journal Apr 2021, 57 (4) 2003505; DOI: 10.1183/13993003.03505-2020
  • A novel locus for exertional dyspnoea in childhood asthma
    Sanghun Lee, Jessica Ann Lasky-Su, Christoph Lange, Wonji Kim, Preeti Lakshman Kumar, Merry-Lynn N. McDonald, Carlos A. Vaz Fragoso, Cecelia Laurie, Benjamin A. Raby, Juan C. Celedón, Michael H. Cho, Sungho Won, Scott T. Weiss, Julian Hecker
    European Respiratory Journal Feb 2021, 57 (2) 2001224; DOI: 10.1183/13993003.01224-2020
  • Functional assessment and phenotypic heterogeneity of SFTPA1 and SFTPA2 mutations in interstitial lung diseases and lung cancer
    Marie Legendre, Afifaa Butt, Raphaël Borie, Marie-Pierre Debray, Diane Bouvry, Emilie Filhol-Blin, Tifenn Desroziers, Valérie Nau, Bruno Copin, Florence Dastot-Le Moal, Mélanie Héry, Philippe Duquesnoy, Nathalie Allou, Anne Bergeron, Julien Bermudez, Aurélie Cazes, Anne-Laure Chene, Vincent Cottin, Bruno Crestani, Jean-Charles Dalphin, Christine Dombret, Bérénice Doray, Clairelyne Dupin, Violaine Giraud, Anne Gondouin, Laurent Gouya, Dominique Israël-Biet, Caroline Kannengiesser, Aurélie Le Borgne, Sylvie Leroy, Elisabeth Longchampt, Gwenaël Lorillon, Hilario Nunes, Clément Picard, Martine Reynaud-Gaubert, Julie Traclet, Paul de Vuyst, Aurore Coulomb L'Hermine, Annick Clement, Serge Amselem, Nadia Nathan
    European Respiratory Journal Dec 2020, 56 (6) 2002806; DOI: 10.1183/13993003.02806-2020

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