Mast cells are thought to contribute to allergic airway disease. However, the role of mast cell-
produced mediators, such as tumour necrosis factor (TNF), for the development of allergic …

BACKGROUND: Mast cells, IgE, and TNF, which have been implicated in human atopic
asthma, contribute significantly to the allergic airway inflammation induced by ovalbumin …

We have investigated the role of TNF‐α in mast cell‐mediated late airway
hyperresponsiveness (AHR) using mast cell‐deficient WBB6F1‐W/Wv (W/Wv) mice in a …

Tumour necrosis factor (TNF) is an important inflammatory cytokine produced by several cell
types. To test the hypothesis that there is cell‐type‐specific regulation and not redundancy of …

The mechanisms involved in nonatopic asthma are poorly defined. In particular, the
importance of mast cells in the development of nonatopic asthma is not clear. In the mouse …

Therapeutics targeting specific mechanisms of asthma have shown promising results in
mouse models of asthma. However, these successes have not transferred well to the clinic …

The importance of mast cells in the development of the allergen-induced airway
hyperreactivity and inflammation associated with asthma remains controversial. We found …

Bronchial asthma, the most prevalent cause of significant respiratory morbidity in the
developed world, typically is a chronic disorder associated with long-term changes in the …

Mast cell-deficient mice are a key for investigating the function of mast cells in health and
disease. Allergic airway disease induced as a Th2-type immune response in mice is …

The histochemical characteristics of human basophils and tissue mast cells were described
over a century ago by Paul Ehrlich. When mast cells are activated by an allergen that binds …