Acute exacerbations of asthma are frequently caused by viral infections, but the
inflammatory mechanisms in virus-induced asthma are poorly understood. The aim of the …

We examined the feasibility of using induced sputum to evaluate the airway inflammatory
response to natural acute respiratory virus infections. We recruited eight asthmatics and nine …

Background The nature of bronchial mucosal inflammation and its physiologic and clinical
significance in rhinovirus-induced asthma exacerbations is unclear. We investigated …

Rationale: Virus-induced asthma is characterized by marked neutrophil influx and
eosinophil degranulation, suggesting a mode of immunopathogenesis different from that of …

Airway inflammation in severe asthma is not well characterized but may involve neutrophils.
We have compared induced sputum profiles in patients with asthma of varying severity and …

To infer possible mechanisms of acute airway inflammation and mucus hypersecretion in
acute severe asthma, we performed cellular and biochemical analysis on sputum from 18 …

Infection with respiratory viruses, including rhinoviruses, influenza virus, and respiratory
syncytial virus, exacerbates asthma, which is associated with processes such as airway …

Lower respiratory tract infections by respiratory syncytial virus (RSV) are the foremost cause
of infant hospitalization and are implicated in lasting pulmonary impairment and the …

Neutrophil infiltration is a major feature in the pathogenesis of the common cold, and
respiratory viral infection is the major cause of asthma exacerbations. The factors regulating …

Background Neutrophils are increased in the airways and in induced sputum of severe
asthma patients. We determined the expression of activation markers from circulating …