Interleukin (IL)-4, IL-5 and interferon (IFN)-gamma are thought to play an important role in
chronic airway inflammation in asthmatic subjects. Increased airways responsiveness and …

In contrast to methacholine, a stimulus that induces airway constriction mainly by" direct"
stimulation of airway smooth muscle cells, AMP airway responsiveness reflects" indirectly" …

Nocturnal symptoms are common in asthma, even when patients are regularly seen at an
outpatient clinic. Inflammation is generally accepted as a general feature of asthma and the …

At present there is some indirect evidence for increased nocturnal inflammation in patients
suffering from nocturnal asthma: 1. Circulating eosinophil numbers and activation, as …

Background: Increased nocturnal airways narrowing (NAN) in asthma is thought to occur as
the result of intensification of inflammatory processes in the airways. In this study we …

Study Design From 4 wk before the start of the study subjects were allowed to use inhaled
bronchodilators only (salbutamol or ipratropiumbromide). At 2 wk before the study, the …

Increased nocturnal airway narrowing is thought to occur as a consequence of an
intensification of inflammatory processes at night. Lymphocyte and alveolar macrophage (AM) …

Explores various studies about the role of airway inflammation in the development of nocturnal
asthma. Anti-inflammatory treatment regimens; Airway responsiveness to indirect acting …

… This would be supported by the finding that the higher the PGD2, the more responsive the
airways to histamine as measured by the PCzO (Y. Oosterhoff, SE Overbeek, R. Douma, JA …

Counting of inflammatory cells in human airway biopsy specimens is difficult because
immunopositive cells are present in varying density in lung tissue. The goal of our study was to …