The microbiome in respiratory medicine: current challenges and future perspectives

…, PL Molyneaux, R Paredes, VP Brocal… - European …, 2017 - Eur Respiratory Soc
The healthy lung has previously been considered to be a sterile organ because standard
microbiological culture techniques consistently yield negative results. However, culture-…

Symbionts and pathogens: what is the difference?

V Pérez-Brocal, A Latorre, A Moya - Between pathogenicity and …, 2011 - Springer
The ecological relationships that organisms establish with others can be considered as broad
and diverse as the forms of life that inhabit and interact in our planet. Those interactions …

Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota

…, M Urpi-Sarda, M Sabater, V Pérez-Brocal… - The ISME …, 2018 - academic.oup.com
Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease
(CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is …

A small microbial genome: the end of a long symbiotic relationship?

V Pérez-Brocal, R Gil, S Ramos, A Lamelas, M Postigo… - Science, 2006 - science.org
Intracellular bacteria are characterized by genome reduction. The 422,434–base pair
genome of Buchnera aphidicola BCc, primary endosymbiont of the aphid Cinara cedri, is ∼200 …

[HTML][HTML] Immunity and other defenses in pea aphids, Acyrthosiphon pisum

…, A Moya, A Nakabachi, BJ Parker, V Pérez-Brocal… - Genome biology, 2010 - Springer
Background Recent genomic analyses of arthropod defense mechanisms suggest conservation
of key elements underlying responses to pathogens, parasites and stresses. At the …

[PDF][PDF] Microbiota alterations in proline metabolism impact depression

…, J Serena, J Gich, L Ramio-Torrenta, V Pérez-Brocal… - Cell metabolism, 2022 - cell.com
The microbiota-gut-brain axis has emerged as a novel target in depression, a disorder with
low treatment efficacy. However, the field is dominated by underpowered studies focusing on …

[PDF][PDF] Organelles in Blastocystis that blur the distinction between mitochondria and hydrogenosomes

A Stechmann, K Hamblin, V Pérez-Brocal, D Gaston… - Current biology, 2008 - cell.com
Blastocystis is a unicellular stramenopile of controversial pathogenicity in humans [1, 2].
Although it is a strict anaerobe, Blastocystis has mitochondrion-like organelles with cristae, a …

Severity-related changes of bronchial microbiome in chronic obstructive pulmonary disease

…, X Pomares, R Ferrari, V Pérez-Brocal… - Journal of clinical …, 2014 - Am Soc Microbiol
Bronchial colonization by potentially pathogenic microorganisms (PPMs) is often demonstrated
in chronic obstructive pulmonary disease (COPD), but culture-based techniques identify …

[PDF][PDF] Caudovirales bacteriophages are associated with improved executive function and memory in flies, mice, and humans

…, C Zapata-Tona, S Pedraza, V Pérez-Brocal… - Cell Host & Microbe, 2022 - cell.com
Growing evidence implicates the gut microbiome in cognition. Viruses, the most abundant life
entities on the planet, are a commonly overlooked component of the gut virome, dominated …

[HTML][HTML] Beyond cells–The virome in the human holobiont

R García-López, V Pérez-Brocal, A Moya - Microbial Cell, 2019 - ncbi.nlm.nih.gov
Viromics, or viral metagenomics, is a relatively new and burgeoning field of research that
studies the complete collection of viruses forming part of the microbiota in any given niche. It …