Chronic pulmonary infection with Pseudomonas aeruginosa is responsible for most of the
morbidity and mortality in cystic fibrosis (CF). Once established as a biofilm, chronic P. …

Chronic Pseudomonas aeruginosa biofilm lung infection in cystic fibrosis patients is the best
described biofilm infection in medicine. The initial focus can be the paranasal sinuses and …

The present study was undertaken to investigate the appearance and location of Pseudomonas
aeruginosa in the cystic fibrosis (CF) lung and in sputum. Samples include preserved …

Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous
mycobacteria, are emerging as an important global threat to individuals with cystic …

Quorum sensing (QS) denotes a density-dependent mode of inter-bacterial communication
based on signal transmitter molecules. Active QS is present during chronic infections with the …

Mannose-binding lectin (MBL) is a key factor in innate immunity, and lung infections are the
leading cause of morbidity and mortality in cystic fibrosis (CF). Accordingly, we investigated …

… “More radically, I would suggest that we don't need international comparisons. Rather,
what we need is … Dembski, T. Pressler, and G. Rault have no conflicts of interest to report. …

Background Lumacaftor and ivacaftor combination treatment showed efficacy in patients
aged 12 years or older with cystic fibrosis homozygous for F508del-cystic fibrosis …

… 8-oxodG promotes the misincorporation of adenine in the replication round, producing G:C to
T… The unpaired t test was used for comparison of the data for the hypermutable isolates and …

BACKGROUND: Since 1989, CF-patients intermittently colonized with Pseudomonas
aeruginosa have been treated with inhaled colistin and oral ciprofloxacin in the Copenhagen CF-…