Tiotropium, a novel once-daily inhaled anticholinergic, has been shown to improve lung
function over a 24-h period. In order to extend these findings, health-outcomes were evaluated …

… With 84 completed patients, the study had 95% power to detect a difference of 100 mL in
peak FEV 1 (α = .025, 1-sided) by using a 2-group t test, assuming an SD of 250 mL for within-…

BACKGROUND A study was undertaken to evaluate and compare the efficacy and safety of
tiotropium and ipratropium during long term treatment in patients with stable chronic …

The efficacy and safety of salmeterol alone was compared with the combination of salmeterol
plus ipratropium and with placebo during long-term treatment in patients with stable …

This dose-ranging study assessed the bronchodilator efficacy and tolerability of indacaterol,
a novel once-daily inhaled β 2 -agonist, in subjects clinically diagnosed with COPD. …

Background The efficacy and safety of Symbicort® 1 (budesonide and formoterol in a single
inhaler) were compared with those of a high dose of the commonly used corticosteroid …

… was powered to include a total of 60 patients required to detect a difference in mean FEV 1
of 60 mL between treatments with 90% power at the 5% level (two sided) using a paired t test. …

Objective Respimat® Soft Mist™ Inhaler (SMI) is a novel, propellant-free device that
significantly increases lung deposition compared with pressurised metered-dose inhalers (pMDIs). …

… RE Jonkers, TA Bantje and R Aalbers were involved in the design of the study, data collection,
analysis and interpretation and the drafting of the paper. All authors had complete access …

… Ericsson a , TA Bantje b , RM Huber c , S. Borg a d , ED Bateman e … Mean values for
cost data were compared using parametric tests (t-test) based on the central limit theorem. …