Vascular endothelial growth factor (VEGF) is a pluripotent growth and permeability factor that
has a broad impact on endothelial cell function. The lung tissue is very rich in this protein; …

Apoptosis and the removal of apoptotic cells (termed efferocytosis) are tightly coupled with
the regulation of normal lung structure, both in the developing and adult organism. Processes …

Apoptotic cells can be detected in the parenchyma and airways of patients with chronic
obstructive pulmonary disease (COPD) in greater numbers than seen in normal lungs or those …

Successful repair after tissue injury and inflammation requires resolution of the inflammatory
response and removal of extracellular matrix breakdown products. We have examined …

Removal of cells dying by apoptosis is essential to normal development, maintenance of
tissue homeostasis, and resolution of inflammation. Surfactant protein A (SP-A) and surfactant …

Cystic fibrosis is characterized by an early and sustained influx of inflammatory cells into the
airways and by release of proteases. Resolution of inflammation is normally associated with …

PPARγ is a member of a family of nuclear receptors/ligand–dependent transcription factors,
which bind to hormone response elements on target gene promoters. An antiproliferative …

Statins are potent, cholesterol-lowering agents with newly appreciated, broad anti-inflammatory
properties, largely based upon their ability to block the prenylation of Rho GTPases, …

… RW Vandivier has received funds for research, salary support and funds for a staff member
… Miravitlles M, Murio C, Guerrero T, Gisbert R. Costs of chronic bronchitis and COPD: a 1-year …

Rationale: Efficient removal of apoptotic cells is essential for the resolution of acute
pulmonary inflammation. Alveolar macrophages ingest apoptotic cells less avidly than other …