Antitumor immunity driven by intratumoral dendritic cells contributes to the efficacy of
anthracycline-based chemotherapy in cancer. We identified a loss-of-function allele of the gene …

The purpose of this review was to modify the prevailing view that neutrophil elastase (NE) is
mainly a matrix-degrading enzyme. Recent observations indicate that the role of NE in …

… In addition, up to five times higher ATP concentrations are measured in fresh BALF directly
after collection than in frozen BALF samples (M. Idzko, unpublished data). Thus, the ATP …

Rationale: There is a need for new agents capable of suppressing the inflammatory response
in chronic obstructive pulmonary disease. Objectives: This study evaluated the effects of …

… Detailed information is listed in the Materials and Methods in the online supplement. … The
morphometrical assessment is detailed in Materials and Methods in the online supplement (27)…

Extracellular ATP acts as a “danger signal” and can induce inflammation by binding to
purinergic receptors. Chronic obstructive pulmonary disease is one of the most common …

The development of cigarette smoke-induced pulmonary changes in C57 Bl/6J and DBA/2
mice was investigated. Both strains are sensitive to oxidants and C57Bl/6J mice are …

… Elastin was extracted by successive extraction with 1 M NaCl, chloroform-methanol, and
by hot alkali treatment at 98 C for 50 min in 0.1 N NaOH (18). The insoluble, defatted residue …

Although neurokinin 1 receptor antagonists prevent ethanol (EtOH)-induced gastric lesions,
the mechanisms by which EtOH releases substance P (SP) and SP damages the mucosa …

Background Cannabinoids modulate fibrogenesis in scleroderma. Ajulemic acid (AjA) is a
non-psychoactive synthetic analogue of tetrahydrocannabinol that can bind the peroxisome …