Globally, there are now over 160 million confirmed cases of COVID-19 and more than 3
million deaths. While the majority of infected individuals recover, a significant proportion …

The CONSORT 2010 statement provides minimum guidelines for reporting randomised trials.
Its widespread use has been instrumental in ensuring transparency in the evaluation of …

The SPIRIT 2013 statement aims to improve the completeness of clinical trial protocol
reporting by providing evidence-based recommendations for the minimum set of items to be …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is associated
with a range of persistent symptoms impacting everyday functioning, known as post-COVID-19 …

Background Device-detected atrial high-rate episodes (AHREs) are atrial arrhythmias detected
by implanted cardiac devices. AHREs resemble atrial fibrillation but are rare and brief. …

… Author Contributions: Drs Calvert and Brundage had full access to all of the data in the study
and … Dr Calvert reported that she has served as a consultant to Amgen. No other disclosures …

Background The aim of this study was to systematically synthesise the global evidence on
the prevalence of persistent symptoms in a general post COVID-19 population. Methods A …

Importance Patient-reported outcome (PRO) data from clinical trials can provide valuable
evidence to inform shared decision making, labeling claims, clinical guidelines, and health …

Composite outcomes, in which multiple end points are combined, are frequently used as
primary outcome measures in randomized trials and are often associated with increased …

Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease
(AD), suggesting that activation of this innate immune receptor may be a useful therapeutic …