User profiles for M. P. Conomos
Matthew P ConomosUniversity of Washington Verified email at uw.edu Cited by 6477 |
[HTML][HTML] Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …
Genetic analyses of diverse populations improves discovery for complex traits
…, C Caberto, S Canizales-Quinteros, MP Conomos… - Nature, 2019 - nature.com
Genome-wide association studies (GWAS) have laid the foundation for investigations into the
biology of complex traits, drug development and clinical guidelines. However, the majority …
biology of complex traits, drug development and clinical guidelines. However, the majority …
Detectable clonal mosaicism from birth to old age and its relationship to cancer
…, S Bennett, SC Nelson, SM Gogarten, MP Conomos… - Nature …, 2012 - nature.com
We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions
and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for …
and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for …
[PDF][PDF] Control for population structure and relatedness for binary traits in genetic association studies via logistic mixed models
Linear mixed models (LMMs) are widely used in genome-wide association studies (GWASs)
to account for population structure and relatedness, for both continuous and binary traits. …
to account for population structure and relatedness, for both continuous and binary traits. …
Robust inference of population structure for ancestry prediction and correction of stratification in the presence of relatedness
Population structure inference with genetic data has been motivated by a variety of applications
in population genetics and genetic association studies. Several approaches have been …
in population genetics and genetic association studies. Several approaches have been …
[PDF][PDF] Model-free estimation of recent genetic relatedness
MP Conomos, AP Reiner, BS Weir… - The American Journal of …, 2016 - cell.com
Genealogical inference from genetic data is essential for a variety of applications in human
genetics. In genome-wide and sequencing association studies, for example, accurate …
genetics. In genome-wide and sequencing association studies, for example, accurate …
Genetic association testing using the GENESIS R/Bioconductor package
The Genomic Data Storage (GDS) format provides efficient storage and retrieval of genotypes
measured by microarrays and sequencing. We developed GENESIS to perform various …
measured by microarrays and sequencing. We developed GENESIS to perform various …
[PDF][PDF] Genetic diversity and association studies in US Hispanic/Latino populations: applications in the Hispanic Community Health Study/Study of Latinos
MP Conomos, CA Laurie, AM Stilp, SM Gogarten… - The American Journal of …, 2016 - cell.com
US Hispanic/Latino individuals are diverse in genetic ancestry, culture, and environmental
exposures. Here, we characterized and controlled for this diversity in genome-wide …
exposures. Here, we characterized and controlled for this diversity in genome-wide …
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
…, DW Bowden, JG Broome, MP Conomos… - Nature …, 2020 - nature.com
Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs)
associated with complex phenotypes. Commonly used RV association tests have …
associated with complex phenotypes. Commonly used RV association tests have …
GWASTools: an R/Bioconductor package for quality control and analysis of genome-wide association studies
SM Gogarten, T Bhangale, MP Conomos… - …, 2012 - academic.oup.com
GWASTools is an R/Bioconductor package for quality control and analysis of genome-wide
association studies (GWAS). GWASTools brings the interactive capability and extensive …
association studies (GWAS). GWASTools brings the interactive capability and extensive …