FGF9 prevents pleural fibrosis induced by intrapleural adenovirus injection in mice
…, V Besnard, J Marchal-Sommé… - … of Physiology-Lung …, 2017 - journals.physiology.org
Fibroblast growth factor 9 (FGF9) is necessary for fetal lung development and is expressed
by epithelium and mesothelium. We evaluated the role of FGF9 overexpression on adenoviral…
by epithelium and mesothelium. We evaluated the role of FGF9 overexpression on adenoviral…
Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema
D Goven, A Boutten, V Leçon-Malas, J Marchal-Sommé… - Thorax, 2008 - thorax.bmj.com
Background: Oxidative stress, resulting from the increased oxidative burden and decreased
level of antioxidant proteins, plays a role in the pathophysiology of smoking-related …
level of antioxidant proteins, plays a role in the pathophysiology of smoking-related …
Cutting edge: nonproliferating mature immune cells form a novel type of organized lymphoid structure in idiopathic pulmonary fibrosis
J Marchal-Sommé, Y Uzunhan… - The Journal of …, 2006 - journals.aai.org
Ectopic formation of secondary lymphoid tissue is initiated by the local attraction of naive T
and B cells. In this study, we describe a novel type of organized lymphoid structure in the lung …
and B cells. In this study, we describe a novel type of organized lymphoid structure in the lung …
Three‐dimensional investigation and scoring of extracellular matrix remodeling during lung fibrosis using multiphoton microscopy
The organization of collagen during fibrotic processes is poorly characterized because of the
lack of appropriate methodologies. Here we show that multimodal multiphoton microscopy …
lack of appropriate methodologies. Here we show that multimodal multiphoton microscopy …
[HTML][HTML] The hedgehog system machinery controls transforming growth factor-β–dependent myofibroblastic differentiation in humans: Involvement in idiopathic …
…, EF Moshai, S Brayer, J Marchal-Somme… - The American journal of …, 2012 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown cause. Key signaling
developmental pathways are aberrantly expressed in IPF. The hedgehog pathway plays a …
developmental pathways are aberrantly expressed in IPF. The hedgehog pathway plays a …
Nuclear factor erythroid 2-related factor 2 nuclear translocation induces myofibroblastic dedifferentiation in idiopathic pulmonary fibrosis
…, A Hamimi, V Besnard, J Marchal-Somme… - Antioxidants & redox …, 2013 - liebertpub.com
Aims: Oxidants have been implicated in the pathophysiology of idiopathic pulmonary fibrosis
(IPF), especially in myofibroblastic differentiation. We aimed at testing the hypothesis that …
(IPF), especially in myofibroblastic differentiation. We aimed at testing the hypothesis that …
Modulation of bleomycin-induced lung fibrosis by serotonin receptor antagonists in mice
A Fabre, J Marchal-Somme… - European …, 2008 - Eur Respiratory Soc
Serotonin (5-hydroxytryptamine; 5-HT) is known to increase proliferation and collagen
synthesis by fibroblasts. Two receptor subtypes, 5-HT2A and 5-HT2B, have been shown to play …
synthesis by fibroblasts. Two receptor subtypes, 5-HT2A and 5-HT2B, have been shown to play …
Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation
…, J Marchal‐Somme, A Hazoume, J Gauldie… - The FASEB …, 2013 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by myofibroblast
proliferation. Transition of epithelial/mesothelial cells into myofibroblasts [epithelial‐to‐…
proliferation. Transition of epithelial/mesothelial cells into myofibroblasts [epithelial‐to‐…
Identification of periplakin as a new target for autoreactivity in idiopathic pulmonary fibrosis
Rationale: Injury to alveolar epithelial cells is central to the pathophysiology of idiopathic
pulmonary fibrosis (IPF). An abnormal autoimmune response directed against antigens of the …
pulmonary fibrosis (IPF). An abnormal autoimmune response directed against antigens of the …
Dendritic cells accumulate in human fibrotic interstitial lung disease
J Marchal-Sommé, Y Uzunhan… - American journal of …, 2007 - atsjournals.org
Rationale: There is growing evidence that resident cells, such as fibroblasts and epithelial
cells, can drive the persistent accumulation of dendritic cells (DCs) in chronically inflamed …
cells, can drive the persistent accumulation of dendritic cells (DCs) in chronically inflamed …