Interstitial lung disease is a common manifestation of rheumatoid arthritis; however, little is
known about factors that influence its prognosis. The aim of the present study was to …

Allergic diseases are a growing health concern in industrialized countries. Despite a number
of effective therapeutic options for the prevention and treatment of the pathophysiologic …

Bacterial DNA and its synthetic immunostimulatory oligodeoxynucleotide analogs (ISS-ODN)
activate innate immunity and promote Th1 and cytotoxic T-lymphocyte immune responses. …

Immunostimulatory sequence (ISS) DNA containing unmethylated CpG dinucleotides stimulate
NK and APC to secrete proinflammatory cytokines, including IFN-αβ and-γ, TNF-α, and IL-…

Immunostimulatory DNA sequences (ISS, also known as CpG motifs) are pathogen-associated
molecular patterns that are potent stimulators of innate immunity. We tested the ability of …

… van Uden; … van Uden … van Uden, Hiroko Kobayashi, D. Broide, Eyal Raz; DNA
Immunotherapeutics: New Potential Treatment Modalities for Allergic Disease. Int Arch Allergy …

… , Van Uden, Tighe, and Raz, submitted for publication). Therefore, there seems to be an
important balance between the ratios of different types of immunologically active sequences in …

Background: Identification of risk factors and causes of stroke is key to optimize treatment and
prevent recurrence. Up to one-third of young patients with stroke have a cryptogenic stroke …

HIF (hypoxia-inducible factor) is the main transcription factor activated by low oxygen tensions.
HIF-1α (and other α subunits) is tightly controlled mostly at the protein level, through the …

Background Cerebral small vessel disease (SVD) is a frequent finding on CT and MRI scans
of elderly people and is related to vascular risk factors and cognitive and motor impairment, …