During the past decade a plethora of studies have unravelled the multiple roles of nitric oxide
(NO) in airway physiology and pathophysiology. In the respiratory tract, NO is produced by …

… Furthermore, Ricciardolo et al found an NO dependent modulation of bronchoconstriction
induced by bradykinin, citric acid, tachykinin NK 1 selective agonist, and protease activated …

… major domains, the reductase and oxygenase domains (Ricciardolo, 2003a). The C-terminal …
heme moiety and to couple the reductase and oxygenase domains (Ricciardolo, 2003a). …

… (F ENO ), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC)
and other measurements. For EBC and for F … For EBC and F ENO , new developments and …

In the last decade, the analysis of bronchial biopsies and lung parenchyma obtained from
chronic obstructive pulmonary disease (COPD) patients compared with those from smokers …

Although alteration of airway pH may serve an innate host defense capacity, it also is implicated
in the pathophysiology of obstructive airway diseases. Acid-induced asthma appears in …

Background Asthma is classified according to severity and inflammatory phenotype and is
likely to be distinguished by specific microRNA (miRNA) expression profiles. Objective We …

Background: T helper (Th)‐17 cells are a subset of T helper lymphocytes that exert regulatory
activities. Recently, it has been reported that serum interleukin (IL)‐17 levels are high in …

Activation of the transcription factor signal transducer and activator of transcription (STAT)‐4
is critical for the differentiation of T‐helper 1 cells/type‐1 cytotoxic T‐cells and the production …

… T h 17 cells seem to play a relevant role in SA related to bronchial neutrophils.7, 8 IL-17A/F
increased expression has been demonstrated in bronchial mucosa of moderate-to-severe …