With knowledge of the molecular behaviour of the cystic fibrosis transmembrane conductance
regulator (CFTR), its physiological role and dysfunction in cystic fibrosis (CF), therapeutic …

Among the diverse physiological functions exerted by calcium signaling in living cells, its role
in the regulation of protein biogenesis and trafficking remains incompletely understood. In …

… ^aCentre de Perharidy, ManRos Therapeutics, Roscoff, France; ^bDepartment
of Pharmacological and Physiological Sciences, The University of Chicago, Chicago, Ill …

… F to relative (or intrinsic) angular frequency a : N = F / a. The directional variance density F(f,9…
models the way the wave energy (or variance) spreads over frequency f and direction 0. _^ …

… in Becq et al.12 For peritoneal macrophages, the procedure is essentially as described in
Becq et al.… Gabel (Pfizer Inc) for discussion and for having provided Tenidap and UK5099; F. …

Background and purpose: TRPM4 and TRPM5 are calcium‐activated non‐selective cation
channels with almost identical characteristics. TRPM4 is detected in several tissues including …

In the disease cystic fibrosis (CF), the most common mutation delF508 results in
endoplasmic reticulum retention of misfolded CF gene proteins (CFTR). We show that the α-1,2-…

The cystic fibrosis transmembrane conductance regulator (CFTR) is present in mature sperm
and is required for sperm motility and capacitation. Both these processes are controlled by …

Background: Most patients with cystic fibrosis (CF) have a ΔF508 mutation resulting in
abnormal retention of mutant gene protein (ΔF508-CFTR) within the cell. This study was …

The deletion of Phe508 (ΔF508) in the first nucleotide binding domain (NBD1) of CFTR is
the most common mutation associated with cystic fibrosis. The ΔF508‐CFTR mutant is …