Aging is known to be associated with an increased prevalence of multiple chronic diseases,
which frequently causes the use of complex therapeutic regimens. The aging process is …

Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma
longa). It has been used for centuries in Ayurveda (Indian traditional medicine) for the …

… Carlo Pedone obtained his Doctor of Chemistry degree cum laude in 1961. He began his
scientific career in the field of Macromolecular Chemistry under the guidance of Prof. Paolo …

BACKGROUND: Atrial fibrillation is the most common cardiac arrhythmia, and no current
therapy is ideal for control of this condition. Experimental studies suggest that angiotensin II-…

OBJECTIVES: To determine the prevalence of adverse drug reaction (ADR)‐related hospital
admissions in an older population, to describe the most common clinical manifestations and …

Carbonic anhydrase (CA) IX is a plasma membrane-associated member of the α-CA enzyme
family, which is involved in solid tumor acidification. It is a marker of tumor hypoxia and a …

Hedgehog signalling is crucial for development and is deregulated in several tumours,
including medulloblastoma. Regulation of the transcriptional activity of Gli (glioma-associated …

PURPOSE: Cognitive impairment is a common, potentially reversible condition among older
patients with heart failure. Because cerebral metabolic abnormalities have been associated …

Background: Arterial hypotension has been associated with increased risk of dementia in
some large prospective studies; and cognitive impairment is common among elderly with left …

Modulating angiogenesis is an attractive goal because many pathological conditions depend
on the growth of new vessels. Angiogenesis is mainly regulated by the VEGF, a mitogen …