Effects of flavonoids on the release of reactive oxygen species by stimulated human neutrophils: Multivariate analysis of structure-activity relationships (SAR)

B Limasset, C Le Doucen, JC Dore, T Ojasoo… - Biochemical …, 1993 - Elsevier
… principal chemical modifications concern the C ring in our population of molecules; C&
unsaturation, a keto group at C4 and a hydroxyl group at C, which can be glycosylated as in …

Wine phenolic antioxidants inhibit AP-1 transcriptional activity

…, JP Cristol, S Delbosc, C Le Doucen… - Journal of Agricultural …, 2001 - ACS Publications
Some of the beneficial effects of moderate wine consumption may be related to the antioxidant
properties of polyphenolic compounds containing tannins, flavonoids, and phenolic acids. …

Increased oxygen species generation in blood monocytes of asthmatic patients

I Vachier, M Damon, C Le Doucen… - American Review of …, 1992 - atsjournals.org
… Cells were then incubated in petri dishes with 2 ml RPMI 1640medium and 20% fetal calf
serum for 2 h at 37 C in a humid atmosphere of 95070 air and 5% CO2 , The monolayers …

Enhancement of reactive oxygen species formation in stable and unstable asthmatic patients

I Vachier, P Chanez, C Le Doucen… - European …, 1994 - Eur Respiratory Soc
There is increasing evidence to suggest that human blood polymorphonuclear neutrophils (PMNs)
and monocytes play an important role in the inflammatory processes of asthma. In …

Antioxidant activity of micronized diosmin on oxygen species from stimulated human neutrophils

B Cypriani, B Limasset, ML Carrie, C Le Doucen… - Biochemical …, 1993 - Elsevier
c by SOD-sensitive agents was determined after addition of SOD (3Opg). Ferricytochrome
c … The results represent means C SEM of triplicate determinations in three experiments. …

Cellular protein kinase C activity in asthma.

…, T Radeau, C Le Doucen, C Leger… - American journal of …, 1997 - atsjournals.org
Protein kinase C (PKC) is a primary group of enzymes mediating signal transduction for a
wide variety of functions in many different cell types. Its activation has been implicated in …

Reciprocal effects between opioid peptides and human polymorphonuclear leukocytes—II: Enhancement of phorbol myristate acetate-induced respiratory burst in …

A Slaoui-Hasnaoui, MC Guerin, C Le Doucen… - Biochemical …, 1992 - Elsevier
Activated oxygen species (AOS) have often been shown to promote strong modifications in
peptide structures and thus in their biological functions. In the present study, the …

Affinity chromatography at sub-zero temperatures: A model study with porcine pancreatic elastase

C Balny, C Le Doucen, P Douzou, JG Bieth - Journal of Chromatography A, 1979 - Elsevier
… The specificity was checked with ovalbumin, cytochrome c, trypsin and c-chymotrypsin
under conditions identical with those used for elastase. With ovalbumin and cytochrome c, the …

Temperature dependence of the absorption in the region beyond the 4.3-μm band head of CO2. 2: N2 and O2 broadening

C Cousin, R Le Doucen, C Boulet, A Henry - Applied optics, 1985 - opg.optica.org
In this paper we present the first accurate determination, from laboratory measurements, of
the temperature dependence of CO_2 continuous absorption beyond the ν_3 band head, …

Imaging reactive oxygen species in asthma

I Vachier, CL Doucen, J Loubatière… - Journal of …, 1994 - Wiley Online Library
… These first observations were obtained with conventional methods such as ferricytochrome
c assays to detec superoxide anions and scopoletin assays to detect hydrogen peroxide. …