There is current evidence to demonstrate a close association between fungal sensitisation
and asthma severity. Whether such an association is causal remains to be confirmed, but this …

Human pulmonary fibrosis is characterized by alveolar epithelial cell injury, areas of type II
cell hyperplasia, accumulation of fibroblasts and myofibroblasts, and the deposition of …

Interstitial lung fibrosis can develop as a consequence of occupational or medical exposure,
as a result of genetic defects, and after trauma or acute lung injury leading to …

Ligands from dying cells are a source of Toll-like receptor (TLR) activating agents. Although
TLR3 is known to respond to RNA from necrotic cells, the relative importance of this …

Alternatively activated (M2) macrophages play critical roles in diverse chronic diseases,
including parasite infections, cancer, and allergic responses. However, little is known about the …

The pleiotropic growth factor TGFβ 1 promotes many of the pathogenic mechanisms observed
in lung fibrosis and airway remodeling, such as aberrant extracellular matrix deposition …

To explore the mechanism of immunosuppression associated with sepsis, we developed a
murine model of sepsis-induced Pseudomonas aeruginosa pneumonia. CD-1 mice …

Rationale: Myofibroblasts are primary effector cells in idiopathic pulmonary fibrosis (IPF).
Defining mechanisms of myofibroblast differentiation may be critical to the development of …

Pulmonary fibrosis is characterized by alterations in fibroblast phenotypes resulting in
excessive extracellular matrix accumulation and anatomic remodeling. Current therapies for this …

The median survival of patients with idiopathic pulmonary fibrosis (IPF) continues to be
approximately 3 years from the time of diagnosis, underscoring the lack of effective medical …