Objective— The aim of this study was to investigate the influence of interferon-γ (IFN-γ) on
atherosclerosis in low density lipoprotein receptor (LDLR)–null mice. Methods and Results— …

Rationale: Angiographic investigation suggests that pulmonary vascular remodeling in
smokers is characterized by distal pruning of the blood vessels. Objectives: Using volumetric …

Rationale: Muscle wasting in chronic obstructive pulmonary disease (COPD) is associated
with a poor prognosis and is not readily assessed by measures of body mass index (BMI). …

Background— The influence of complement activation on atherosclerosis is not well understood.
The purpose of this study was to examine the effects of C3 deficiency on the extent and …

Background Observational studies suggest that beta-blockers may reduce the risk of
exacerbations and death in patients with moderate or severe chronic obstructive pulmonary …

Rationale: The role of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins)
in the development or progression of interstitial lung disease (ILD) is controversial. Objectives…

Uncontrolled pilot studies demonstrated promising results of endoscopic lung volume
reduction using emphysematous lung sealant (ELS) in patients with advanced, upper lobe …

Background Prior studies of clinical prognostication in idiopathic pulmonary fibrosis (IPF)
using computed tomography (CT) have often used subjective analyses or have evaluated …

Rationale: Cor pulmonale (right ventricular [RV] dilation) and cor pulmonale parvus (RV
shrinkage) are both described in chronic obstructive pulmonary disease (COPD). The …

Background Exposure to cigarette smoke has been shown to lead to vascular remodelling.
Computed tomography (CT) imaging measures of vascular pruning have been associated …