Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors

LV Sequist, BA Waltman, D Dias-Santagata… - Science translational …, 2011 - science.org
Lung cancers harboring mutations in the epidermal growth factor receptor (EGFR) respond
to EGFR tyrosine kinase inhibitors, but drug resistance invariably emerges. To elucidate …

Isolation of circulating tumor cells using a microvortex-generating herringbone-chip

…, M Yu, DT Miyamoto, BA Waltman… - Proceedings of the …, 2010 - National Acad Sciences
Rare circulating tumor cells (CTCs) present in the bloodstream of patients with cancer
provide a potentially accessible source for detection, characterization, and monitoring of …

[HTML][HTML] Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice

…, JS Temel, IT Lennes, S Digumarthy, BA Waltman… - Annals of …, 2011 - Elsevier
… in a pie chart showing frequency of each mutation with regard to all patients tested (A) as
well as in a Venn diagram showing the overlap of patients with more than one mutation (B). …

BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors

…, RB Corcoran, H Ebi, LV Sequist, BA Waltman… - Cancer discovery, 2011 - AACR
Cancers with specific genetic mutations are susceptible to selective kinase inhibitors.
However, there is a wide spectrum of benefit among cancers harboring the same sensitizing …

Nomogram to predict the presence of EGFR activating mutation in lung adenocarcinoma

…, H Chen, JCH Yang, H Ji, B Waltman… - European …, 2012 - Eur Respiratory Soc
Epidermal growth factor receptor (EGFR) tumour genotyping is crucial to guide treatment
decisions regarding the use of EGFR tyrosine kinase inhibitors in nonsmall cell lung cancer (…

MERLIN observations of relativistic ejections from GRS 1915+ 105

…, RE Spencer, AM Stirling, EB Waltman - Monthly Notices of …, 1999 - academic.oup.com
We present high-resolution MERLIN radio images of multiple relativistic ejections from GRS
1915+105 in 1997 October/November. The observations were made at a time of complex …

Development and use of high density fracturing fluid in deep water gulf of Mexico frac and packs

L Rivas, G Navaira, B Bourgeois, B Waltman… - SPE Annual Technical …, 2008 - onepetro.org
In the Gulf of Mexico, there has been an increase in the number of wells drilled to depths
greater than 20,000 ft with bottomhole pressures exceeding 20,000 psi. These deeper wells …

2021 annual report on education spending in England

C Farquharson, L Sibieta, I Tahir, B Waltman - 2021 - econstor.eu
Education spending is the second-largest element of public service spending in the UK
behind health, representing about £99 billion in 2020-21 in today's prices or about 4.5% of …

A one-sided highly relativistic jet from Cygnus X-3

…, RM Hjellming, GG Pooley, EB Waltman - The Astrophysical …, 2001 - iopscience.iop.org
Very Long Baseline Array images of the X-ray binary Cygnus X-3 were obtained 2, 4, and 7
days after the peak of a 10 Jy flare on 1997 February 4. The first two images show a curved …

Pharmacotherapy to reducevisceral fat

GL Blackburn, BA Waltman - Clinical Cornerstone, 2005 - Elsevier
Cardiovascular disease (CVD) is the leading cause of death of men and women in the
United States. The accumulation of visceral adipose tissue, as opposed to subcutaneous fat, …