Results of European post-marketing surveillance of bosentan in pulmonary hypertension
… In 2002, bosentan, an orally administered dual ET A /ET B receptor antagonist, received
orphan drug status and marketing authorisation in the USA and in Europe after two randomised …
orphan drug status and marketing authorisation in the USA and in Europe after two randomised …
[HTML][HTML] Disease and patient characteristics in NP-C patients: findings from an international disease registry
…, E Mengel, FA Wijburg, A Muller, B Schwierin… - Orphanet journal of rare …, 2013 - Springer
Background Niemann-Pick disease type C (NP-C) is a rare neurovisceral disease characterized
by progressive neurodegeneration and premature death. We report data recorded at …
by progressive neurodegeneration and premature death. We report data recorded at …
Selective and total sleep deprivation: effect on the sleep EEG in the rat
T Endo, B Schwierin, AA Borbély, I Tobler - Psychiatry research, 1997 - Elsevier
… Takuro Endo, Barbara Schwierin, Alexander A. Borbgly”, Irene Tobler … is inhibited by an
increased level of REMS propensity; (b) the hypothesis that REMS propensity increases only …
increased level of REMS propensity; (b) the hypothesis that REMS propensity increases only …
Effects of N6-cyclopentyladenosine and caffeine on sleep regulation in the rat
B Schwierin, AA Borbély, I Tobler - European journal of pharmacology, 1996 - Elsevier
To study the role of adenosine in sleep regulation, the adenosine A 1 receptor agonist N 6 -cyclopentyladenosine
(CPA) and the antagonist caffeine were administered to rats. …
(CPA) and the antagonist caffeine were administered to rats. …
Behavioural sleep in the giraffe (Giraffa camelopardalis) in a zoological garden
I Tobler, B Schwierin - Journal of Sleep Research, 1996 - Wiley Online Library
Behavioural sleep was assessed for 152 nights in 5 adult, 2 immature and 1 juvenile giraffes
at a zoological garden, using continuous time‐lapse video recording. Sleep occurred while …
at a zoological garden, using continuous time‐lapse video recording. Sleep occurred while …
[HTML][HTML] Functional impairment of systemic scleroderma patients with digital ulcerations: results from the DUO Registry.
E Hunsche, T Krieg, B Schwierin… - Clinical and …, 2013 - research.manchester.ac.uk
OBJECTIVES: Digital ulcers (DUs) are frequent manifestations of systemic scleroderma (SSc).
This study assessed functional limitations due to DUs among patients enrolled in the …
This study assessed functional limitations due to DUs among patients enrolled in the …
Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry
CP Denton, T Krieg, L Guillevin, B Schwierin… - Annals of the …, 2012 - ard.bmj.com
Objectives The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical
and antibody characteristics, disease course and outcomes of patients with digital ulcers …
and antibody characteristics, disease course and outcomes of patients with digital ulcers …
Elucidating the burden of recurrent and chronic digital ulcers in systemic sclerosis: long-term results from the DUO Registry
…, T Krieg, L Guillevin, B Schwierin… - Annals of the …, 2016 - ard.bmj.com
Objectives Digital ulcers (DUs) occur in up to half of patients with systemic sclerosis (SSc)
and may lead to infection, gangrene and amputation with functional disability and reduced …
and may lead to infection, gangrene and amputation with functional disability and reduced …
[HTML][HTML] Safety experience with bosentan in 146 children 2–11 years old with pulmonary arterial hypertension: results from the European Postmarketing Surveillance …
The oral dual endothelin receptor antagonist bosentan has been shown to improve the short-and
medium-term course of adult pulmonary arterial hypertension (PAH); however, data …
medium-term course of adult pulmonary arterial hypertension (PAH); however, data …
[HTML][HTML] Stable or improved neurological manifestations during miglustat therapy in patients from the international disease registry for Niemann-Pick disease type C …
…, E Mengel, MT Vanier, B Schwierin… - Orphanet journal of rare …, 2015 - Springer
Background Niemann-Pick disease type C (NP-C) is a rare neurovisceral disease characterised
by progressive neurological degeneration, where the rate of neurological disease …
by progressive neurological degeneration, where the rate of neurological disease …