TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma

DF Choy, KM Hart, LA Borthwick, A Shikotra… - Science translational …, 2015 - science.org
Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct
molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n = 51), …

[HTML][HTML] Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

…, H McAuley, EM Harrison, A Shikotra… - The Lancet …, 2021 - thelancet.com
Background The impact of COVID-19 on physical and mental health and employment after
hospitalisation with acute disease is not well understood. The aim of this study was to …

[HTML][HTML] Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization

…, M Richardson, O Elneima, HJC McAuley, A Shikotra… - Nature medicine, 2023 - nature.com
Post-COVID cognitive deficits, including ‘brain fog’, are clinically complex, with both objective
and subjective components. They are common and debilitating, and can affect the ability to …

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma

A Shikotra, DF Choy, CM Ohri, E Doran, C Butler… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Thymic stromal lymphopoietin (TSLP) is a cytokine implicated in the
pathophysiology of asthma through 2 distinct pathways: a TSLP–OX40 ligand (OX40L)–T cell axis …

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

…, S Mosesova, LC Wu, OD Solberg, A Shikotra… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Eosinophilic airway inflammation is heterogeneous in asthmatic patients.
We recently described a distinct subtype of asthma defined by the expression of genes …

[HTML][HTML] Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective …

…, O Elneima, HJC McAuley, A Shikotra… - The Lancet …, 2022 - thelancet.com
Background No effective pharmacological or non-pharmacological interventions exist for
patients with long COVID. We aimed to describe recovery 1 year after hospital discharge for …

Residual lung abnormalities after COVID-19 hospitalization: interim analysis of the UKILD post–COVID-19 study

…, MG Semple, M Sereno, A Shikotra… - American journal of …, 2023 - atsjournals.org
Rationale: Shared symptoms and genetic architecture between coronavirus disease (COVID-19)
and lung fibrosis suggest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-…

Macrophages within NSCLC tumour islets are predominantly of a cytotoxic M1 phenotype associated with extended survival

CM Ohri, A Shikotra, RH Green… - European …, 2009 - Eur Respiratory Soc
There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC)
expressing high numbers of macrophages in their tumour islets. The primary aim of the …

Physical, cognitive and mental health impacts of COVID-19 following hospitalisation–a multi-centre prospective cohort study

…, RA Evans, H McAuley, EM Harrison, A Shikotra… - MedRxiv, 2021 - medrxiv.org
Background The impact of COVID-19 on physical and mental health, and employment
following hospitalisation is poorly understood. Methods PHOSP-COVID is a multi-centre, UK, …

[HTML][HTML] Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based …

…, O Elneima, HJC McAuley, A Shikotra… - The Lancet Regional …, 2023 - thelancet.com
Background The risk factors for recovery from COVID-19 dyspnoea are poorly understood.
We investigated determinants of recovery from dyspnoea in adults with COVID-19 and …