Automated docking of flexible ligands: applications of AutoDock
AutoDock is a suite of C programs used to predict the bound conformations of a small, flexible
ligand to a macromolecular target of known structure. The technique combines simulated …
ligand to a macromolecular target of known structure. The technique combines simulated …
Diagnosis and management of Duchenne muscular dystrophy, part 2: respiratory, cardiac, bone health, and orthopaedic management
…, LE Case, L Cripe, S Hadjiyannakis, AK Olson… - The Lancet …, 2018 - thelancet.com
A coordinated, multidisciplinary approach to care is essential for optimum management of
the primary manifestations and secondary complications of Duchenne muscular dystrophy (…
the primary manifestations and secondary complications of Duchenne muscular dystrophy (…
Structural symmetry and protein function
DS Goodsell, AJ Olson - Annual review of biophysics and …, 2000 - annualreviews.org
▪ Abstract The majority of soluble and membrane-bound proteins in modern cells are
symmetrical oligomeric complexes with two or more subunits. The evolutionary selection of …
symmetrical oligomeric complexes with two or more subunits. The evolutionary selection of …
[HTML][HTML] Structural and functional conservation of the programmed− 1 ribosomal frameshift signal of SARS coronavirus 2 (SARS-CoV-2)
Approximately 17 years after the severe acute respiratory syndrome coronavirus (SARS-CoV)
epidemic, the world is currently facing the COVID-19 pandemic caused by SARS corona …
epidemic, the world is currently facing the COVID-19 pandemic caused by SARS corona …
Idiopathic pulmonary fibrosis (an update) and progressive pulmonary fibrosis in adults: an official ATS/ERS/JRS/ALAT clinical practice guideline
…, B Crestani, L Ho, J Morisset, AL Olson… - American Journal of …, 2022 - atsjournals.org
Background: This American Thoracic Society, European Respiratory Society, Japanese
Respiratory Society, and Asociación Latinoamericana de Tórax guideline updates prior …
Respiratory Society, and Asociación Latinoamericana de Tórax guideline updates prior …
ABT-888, an orally active poly (ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
…, TP McGonigal, JA Meulbroek, AM Olson… - Clinical cancer …, 2007 - AACR
Purpose: To evaluate the preclinical pharmacokinetics and antitumor efficacy of a novel
orally bioavailable poly(ADP-ribose) polymerase (PARP) inhibitor, ABT-888. Experimental …
orally bioavailable poly(ADP-ribose) polymerase (PARP) inhibitor, ABT-888. Experimental …
AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
We describe the testing and release of AutoDock4 and the accompanying graphical user
interface AutoDockTools. AutoDock4 incorporates limited flexibility in the receptor. Several …
interface AutoDockTools. AutoDock4 incorporates limited flexibility in the receptor. Several …
Reduced surface: an efficient way to compute molecular surfaces
Because of their wide use in molecular modeling, methods to compute molecular surfaces
have received a lot of interest in recent years. However, most of the proposed algorithms …
have received a lot of interest in recent years. However, most of the proposed algorithms …
[HTML][HTML] Infliximab for induction and maintenance therapy for ulcerative colitis
…, BG Feagan, W Reinisch, A Olson… - … England Journal of …, 2005 - Mass Medical Soc
Background Infliximab, a chimeric monoclonal antibody directed against tumor necrosis factor
α, is an established treatment for Crohn's disease but not ulcerative colitis. Methods Two …
α, is an established treatment for Crohn's disease but not ulcerative colitis. Methods Two …
Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial
…, JF Colombel, D Rachmilewitz, DC Wolf, A Olson… - The Lancet, 2002 - thelancet.com
Background We did a randomised controlled trial to assess the benefit of maintenance
infliximab therapy in patients with active Crohn's disease who respond to a single infusion of …
infliximab therapy in patients with active Crohn's disease who respond to a single infusion of …