Purpose of Review Increases in ambient levels of air pollutants have been linked to lung
inflammation and remodeling, processes that lead to the development and exacerbation of …

Maternal immune responses can promote allergy development in offspring, as shown in a
model of increased susceptibility to asthma in babies of ovalbumin (OVA)-sensitized and -…

Epidemiological studies reveal increased incidence of lung infection when air pollution particle
levels are increased. We postulate that one risk factor for bacterial pneumonia, prior viral …

There is mounting evidence that environmental exposures can result in effects on health that
can be transmitted across generations, without the need for a direct exposure to the original …

Airway smooth muscle (ASM) cells play important physiological roles in the lung, and abnormal
proliferation of ASM directly contributes to the airway remodeling during development of …

One factor predisposing toward allergic responses is a maternal history of allergy. In a
mouse model of maternal transmission of asthma risk, offspring of asthmatic, but not normal, …

Aberrant DNA hypermethylation at regulatory cis-elements of particular genes is seen in a
plethora of pathological conditions including cardiovascular, neurological, immunological, …

Particulate matter in the air exacerbates airway inflammation (AI) in asthma; moreover,
prenatal exposure to concentrated urban air particles (CAPs) and diesel exhaust particles (DEPs) …

Exposure to environmental particles during pregnancy increases asthma susceptibility of
the offspring. We tested the hypothesis that this transmission continues to F2 and F3 …

The class A scavenger receptors (SR-A) MARCO and SR-AI/II are expressed on lung
macrophages (MΦs) and dendritic cells (DCs) and function in innate defenses against inhaled …