Despite treatment with the current standard-of-care therapies, patients with newly diagnosed
glioblastoma multiforme (GBM) exhibit dismal prognoses. Bevacizumab has demonstrated …

… Values displayed represent Z scores for gene expression of individual samples relative to
the entire sample set. H: In situ hybridization of BCAN and YKL40 in tissue microarray cores of …

The systematic characterization of somatic mutations in cancer genomes is essential for
understanding the disease and for developing targeted therapeutics 1 . Here we report the …

Infections by attaching and effacing (A/E) bacterial pathogens, such as Escherichia coli
O157:H7, pose a serious threat to public health. Using a mouse A/E pathogen, Citrobacter …

Small-cell lung cancer (SCLC) is an exceptionally aggressive disease with poor prognosis.
Here, we obtained exome, transcriptome and copy-number alteration data from …

Identifying and understanding changes in cancer genomes is essential for the development
of targeted therapeutics 1 . Here we analyse systematically more than 70 pairs of primary …

… c, Heat map of the relative average expression of the most strongly enriched genes for
each cluster (log(fold change) of one cluster versus all others, z-score by row) with key genes, …

… –750 m/z and 800–1,500 m/z for singly … m/z) in the Orbitrap at resolution of 60,000 M/ΔM at
m/z 400, followed by MS/MS (profile) scans in the Orbitrap at resolution of 15,000 M/ΔM at m/z …

Tumor-derived cell lines have served as vital models to advance our understanding of
oncogene function and therapeutic responses. Although substantial effort has been made to …

Lung cancer is the leading cause of cancer-related mortality worldwide, with non-small-cell
lung carcinomas in smokers being the predominant form of the disease 1 , 2 . Although …