[HTML][HTML] Novel insights on the use of L-asparaginase as an efficient and safe anti-cancer therapy

M Van Trimpont, E Peeters, Y De Visser, AM Schalk… - Cancers, 2022 - mdpi.com
Simple Summary L-asparaginase (L-ASNase) therapy is key for achieving the very high cure
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …

Combined neonatal stress and young‐adult glucocorticoid stimulation in rats reduce BDNF expression in hippocampus: effects on learning and memory

KHC Choy, Y de Visser, NR Nichols… - …, 2008 - Wiley Online Library
… To assess whether changes in BDNF expression broadly correlated with cognitive ability,
we also tested separate cohorts of animals in the Y-maze test for short term spatial memory, …

[HTML][HTML] Sildenafil attenuates pulmonary inflammation and fibrin deposition, mortality and right ventricular hypertrophy in neonatal hyperoxic lung injury

YP De Visser, FJ Walther, EH Laghmani, H Boersma… - Respiratory …, 2009 - Springer
Background Phosphodiesterase-5 inhibition with sildenafil has been used to treat severe
pulmonary hypertension and bronchopulmonary dysplasia (BPD), a chronic lung disease in …

Allogenic stem cell therapy improves right ventricular function by improving lung pathology in rats with pulmonary hypertension

S Umar, YP de Visser, P Steendijk… - American Journal …, 2009 - journals.physiology.org
Pulmonary arterial hypertension (PAH) is a chronic lung disease that leads to right ventricular
(RV) hypertrophy (RVH), remodeling, and failure. We tested treatment with bone marrow-…

Agonists of MAS oncogene and angiotensin II type 2 receptors attenuate cardiopulmonary disease in rats with neonatal hyperoxia-induced lung injury

…, YP De Visser, L De Vries… - … of Physiology-Lung …, 2013 - journals.physiology.org
de Visserde Visserde Visser YP , Walther FJ , Laghmani EH , Boersma H , van der
Laarse A , Wagenaar GT. Sildenafil attenuates pulmonary inflammation and fibrin deposition, …

Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours

…, J Zimmer, H Benainous, Y De Visser… - EMBO Molecular …, 2022 - embopress.org
The cells with compromised BRCA1 or BRCA2 (BRCA1/2) function accumulate stalled
replication forks, which leads to replication‐associated DNA damage and genomic instability, a …

[HTML][HTML] 17α‐Ethinylestradiol rapidly alters transcript levels of murine coagulation genes via estrogen receptor α

ACA Cleuren, IK van der Linden, YP de Visser… - Journal of Thrombosis …, 2010 - Elsevier
Background: Oral estrogen use is associated with changes in plasma levels of many coagulation
proteins. Objective: To gain more insight into the underlying mechanism of estrogen‐…

Phosphodiesterase-4 inhibition attenuates pulmonary inflammation in neonatal lung injury

YP de Visser, FJ Walther, EH Laghmani… - European …, 2008 - Eur Respiratory Soc
Phosphodiesterase-4 (PDE4) inhibitors may offer novel therapeutic strategies in respiratory
diseases, including asthma and chronic obstructive pulmonary disease. Therefore, selective …

Inactivation of glycoprotein gE and thymidine kinase or the US3-encoded protein kinase synergistically decreases in vivo replication of pseudorabies virus and the …

TG Kimman, N De Wind, T De Bruin, Y De Visser… - Virology, 1994 - Elsevier
Visser have been helpful in Critically reading the manuscript and H. Huipėn has been helpful
with the statistical analysis. The work was partly supported by Intervet, a subsidiary of AKZO…

Effect of vaccination route and composition of DNA vaccine on the induction of protective immunity against pseudorabies infection in pigs

…, BL Haagmans, YE De Visser, MGM De Bruin… - Veterinary Immunology …, 1998 - Elsevier
Vaccination with naked DNA may be an alternative to conventional vaccines because it
combines the efficacy of attenuated vaccines with the biological safety of inactivated vaccines. …