… about the expression of the 3α homologue, although preliminary evidence from our laboratory
suggests high-level expression in the developing trachea and olfactory epithelium (YZ Gu, …

The first formal qualification of safety biomarkers for regulatory decision making marks a
milestone in the application of biomarkers to drug development. Following submission of drug …

Application of any new biomarker to support safety-related decisions during regulated phases
of drug development requires provision of a substantial data set that critically assesses …

We report that MOP3 is a general dimerization partner for a subset of the basic-helix–loop–helix
(bHLH)-PER–ARNT–SIM (PAS) superfamily of transcriptional regulators. We …

Hypoxia inducible factors (HIFs) are heterodimeric transcription factors that regulate a number
of adaptive responses to low oxygen tension. They are composed of α-and β-subunits that …

In an effort to better understand the mechanism of toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin,
we employed an iterative search of human expressed sequence tags to identify novel …

The aryl hydrocarbon receptor (AHR) and the α-class hypoxia inducible factors (HIF1α, HIF2α,
and HIF3α) are basic helix-loop-helix PAS (bHLH-PAS) proteins that heterodimerize with …

Though experimental evidence shows that human bone marrow-derived mesenchymal
stem cells (hBMSCs) are able to suppress T-cell activation and proliferation, the precise …

High-quality Ti-doped ZnO films were grown on Si, thermally grown SiO 2 , and quartz
substrates by atomic layer deposition (ALD) at 200C with various Ti doping concentrations. …

PAS (PER, ARNT, SIM) proteins play important roles in adaptation to low atmospheric and
cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations …